Gene Symbol | RPA4 |
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Entrez Gene | 29935 |
Alt Symbol | HSU24186 |
Species | Human |
Gene Type | protein-coding |
Description | replication protein A4, 30kDa |
Other Description | RF-A protein 4|RP-A p30|replication factor A protein 4|replication protein A 30 kDa subunit|replication protein A complex 34 kd subunit homolog Rpa4|replication protein A4, 34kDa |
Swissprots | Q3SY03 Q13156 |
Accessions | AAM09569 EAX02794 Q13156 BC069791 AAH69791 BC069808 AAH69808 BC069824 AAH69824 BC104013 AAI04014 BC104014 AAI04015 EU832763 ACE87774 GQ129306 ACT64440 HQ448414 ADQ32894 U24186 AAB08488 NM_013347 NP_037479 |
Function | As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. {ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19942684, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:20545304}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19942684}. Note=Localizes to DNA repair foci after DNA damage. |
Tissue Specificity | Preferentially expressed in placental and colon mucosa. Widely expressed at intermediate or lower levels. {ECO:0000269|PubMed:19996105}. |
Top Pathways | DNA replication, Mismatch repair, Homologous recombination, Nucleotide excision repair, Fanconi anemia pathway |
Anti-RPA4 antibody - ab169032 from Abcam
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Anti-RPA4 antibody - ab81772 from Abcam
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Anti-RPA4 antibody - ab135955 from Abcam
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Anti-RPA4 antibody - C-terminal - ab200742 from Abcam
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Anti-RPA4 Antibody (aa212-261) - LS-C199987 from LifeSpan Bioscience
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Anti-RPA4 Antibody (aa180-229) - LS-C111585 from LifeSpan Bioscience
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Anti-RPA4 Antibody (C-Terminus) - LS-C81967 from LifeSpan Bioscience
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Anti-RPA4 Antibody (aa233-261, APC) - LS-C240183 from LifeSpan Bioscience
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Anti-RPA4 Antibody (aa233-261, Biotin) - LS-C240184 from LifeSpan Bioscience
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Anti-RPA4 Antibody (aa233-261, PE) - LS-C240187 from LifeSpan Bioscience
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Anti-RPA4 Antibody (aa233-261, FITC) - LS-C240185 from LifeSpan Bioscience
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Anti-RPA4 Antibody (aa233-261, Azide-free, HRP) - LS-C248038 from LifeSpan Bioscience
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Anti-RPA4 Antibody (aa233-261) - LS-C324767 from LifeSpan Bioscience
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Anti-RPA4 Antibody (aa234-261) - LS-C158883 from LifeSpan Bioscience
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Anti-RPA4 Antibody (aa233-261, AP) - LS-C240181 from LifeSpan Bioscience
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RPA4 Antibody - H00029935-B01P from Novus Biologicals
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RPA4 Antibody - NBP1-58157 from Novus Biologicals
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RPA4 Antibody - NBP1-58156 from Novus Biologicals
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RPA4 Antibody - NBP1-31860 from Novus Biologicals
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RPA4 Antibody - H00029935-D01P from Novus Biologicals
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RPA4 Antibody - H00029935-D01 from Novus Biologicals
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Anti-RPA4 antibody produced in mouse - SAB1400521 from Sigma-Aldrich
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Anti-RPA4 (ab2) antibody produced in rabbit - SAB2102049 from Sigma-Aldrich
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Anti-RPA4 (ab1) antibody produced in rabbit - SAB2102048 from Sigma-Aldrich
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Anti-RPA4 antibody produced in rabbit - SAB1410607 from Sigma-Aldrich
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