Gene Symbol | RPA4 |
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Entrez Gene | 29935 |
Alt Symbol | HSU24186 |
Species | Human |
Gene Type | protein-coding |
Description | replication protein A4, 30kDa |
Other Description | RF-A protein 4|RP-A p30|replication factor A protein 4|replication protein A 30 kDa subunit|replication protein A complex 34 kd subunit homolog Rpa4|replication protein A4, 34kDa |
Swissprots | Q3SY03 Q13156 |
Accessions | AAM09569 EAX02794 Q13156 BC069791 AAH69791 BC069808 AAH69808 BC069824 AAH69824 BC104013 AAI04014 BC104014 AAI04015 EU832763 ACE87774 GQ129306 ACT64440 HQ448414 ADQ32894 U24186 AAB08488 NM_013347 NP_037479 |
Function | As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. {ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19942684, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:20545304}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19942684}. Note=Localizes to DNA repair foci after DNA damage. |
Tissue Specificity | Preferentially expressed in placental and colon mucosa. Widely expressed at intermediate or lower levels. {ECO:0000269|PubMed:19996105}. |
Top Pathways | DNA replication, Mismatch repair, Homologous recombination, Nucleotide excision repair, Fanconi anemia pathway |
Human RPA4 full length protein - ab162273 from Abcam
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Human RPA4 protein fragment - ab162274 from Abcam
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RPA4 Antibody Blocking Peptide - LS-E6127 from LifeSpan Bioscience
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RPA4 Antibody Blocking Peptide - LS-E19817 from LifeSpan Bioscience
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RPA4 Antibody Blocking Peptide - LS-E19818 from LifeSpan Bioscience
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RPA4 Recombinant Protein - H00029935-P01 from Novus Biologicals
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RPA4 Partial Recombinant Protein - H00029935-Q01 from Novus Biologicals
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RPA4-Antibody-C-term-Blocking-Peptide - BP18746b from Abgent, a WuXi AppTec company
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Human RPA4 protein - orb245642 from Biorbyt
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RPA4 Blocking Peptide - 33R-3818 from Fitzgerald
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RPA4 Blocking Peptide - 33R-9743 from Fitzgerald
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RPA4 Blocking Peptide - abx161213 from Abbexa
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RPA4 - H00029935-P01-10 from Acris Antibodies
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RPA4 - H00029935-P01-25 from Acris Antibodies
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RPA4 - H00029935-Q01-10 from Acris Antibodies
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RPA4 - H00029935-Q01-25 from Acris Antibodies
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RPA4 fusion protein - ag12791 from Proteintech Group
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RPA4 fusion protein - Ag12800 from Proteintech Group
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Recombinant Human RPA4, His-tagged - RPA4-2367H from Creative Biomart
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RPA4 Blocking Peptide - CBP3712 from Cohesion Biosciences
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Recombinant human Replication protein A 30 kDa subunit - CSB-EP162494h CSB-BP162494h CSB-MP162494h from Cusabio
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Recombinant Human Replication protein A 30 kDa subunit(RPA4),partial - CSB-RP162494h from Cusabio
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Recombinant Human Replication protein A 30 kDa subunit(RPA4) - CSB-YP622640HU CSB-EP622640HU CSB-BP622640HU CSB-MP622640HU from Cusabio
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RPA4 Protein - abx163138 from Abbexa
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RPA4 - TP310239 from Acris Antibodies
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