NFKBIA

Gene Symbol NFKBIA
Entrez Gene 4792
Alt Symbol IKBA, MAD-3, NFKBI
Species Human
Gene Type protein-coding
Description nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Other Description I-kappa-B-alpha|IkappaBalpha|NF-kappa-B inhibitor alpha|ikB-alpha|major histocompatibility complex enhancer-binding protein MAD3|nuclear factor of kappa light chain gene enhancer in B-cells
Swissprots B2R8L6 P25963
Accessions AAD14949 AAR29599 CAB65110 CAB65111 CAB65112 CAB65113 CAB65114 CAB65556 CAM91165 CBX47574 EAW65875 P25963 AK311515 AK313421 BAG36213 AY033600 AAK51149 BC002601 AAH02601 BC004983 AAH04983 BT007091 AAP35754 BU737609 M69043 AAA16489 NM_020529 NP_065390
Function Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. {ECO:0000269|PubMed:7479976}.
Subcellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. {ECO:0000250}.
Top Pathways Legionellosis, Herpes simplex infection, Viral carcinogenesis, Influenza A, Epstein-Barr virus infection

Phospho-IκBα (Ser32) (14D4) Rabbit mAb (Biotinylated) - 5209 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 14D4
Western blot analysis of extracts from HeLa cells, untreated or treated with human TNF-α (#8902, 20 ng/ml) for 5 minutes, using Phospho-IκBα (Ser32) (14D4) Rabbit mAb (Biotinylated).

IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (PE Conjugate) - 7523 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Mouse
Clonality Polyclonal
Flow cytometric analysis of HeLa cells, treated with Calyculin A #9902 and hTNF-α #8902 (blue) or untreated (green), using IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (PE Conjugate).

IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (Alexa Fluor ® 647 Conjugate) - 8993 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Mouse
Clonality Polyclonal
Flow cytometric analysis of HeLa cells using IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (Alexa Fluor ® 647 Conjugate) (green) compared to a nonspecific negative control antibody (red).

IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (Pacific Blue™ Conjugate) - 13656 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Mouse
Clonality Polyclonal
Flow cytometric analysis of HeLa Cells, untreated (blue) or treated with Calyculin A #9902 and hTNF-α #8902 (green), using IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (Pacific Blue™ Conjugate).

IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (Alexa Fluor ® 488 Conjugate) - 5743 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Mouse
Clonality Polyclonal
Flow cytometric analysis of HeLa cells, using IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (Alexa Fluor ® 488 Conjugate) (blue) compared to Mouse (MOPC-21) mAb IgG1 Isotype Control (Alexa Fluor® 488 Conjugate) #4878 (red).

IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (Biotinylated) - 7543 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (Biotinylated). Streptavidin-HRP #3999 was used for detection.

Phospho-IκBα (Ser32/36) (12C2) Mouse mAb - 5210 from Cell Signaling Technology

Host Mouse
Clonality Monoclonal
Clone 12C2

PhosphoPlus ® IκBα (Ser32/36) Antibody Kit - 9240 from Cell Signaling Technology

Prices $489.00
Sizes 1 kit (10 western blots)
Clonality Polyclonal

Phospho-IκBα (Ser32/36) (5A5) Mouse mAb - 9246 from Cell Signaling Technology

Prices $287.00, $678.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Mouse
Clonality Monoclonal
Clone 5A5
Western blot analysis of extracts from THP-1 cells, differentiated with TPA (#9905, 80 nM for 24 h) and treated with 1 μg/ml LPS for the indicated times, using Phospho-IκBα (Ser32/36) (5A5) Mouse mAb (upper) and IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) #4814 (lower).

Phospho-IκBα (Ser32) (14D4) Rabbit mAb - 2859 from Cell Signaling Technology

Prices $109.00, $287.00, $678.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Monoclonal
Clone 14D4
Western blot analysis of extracts from HeLa and NIH/3T3 cells, untreated or treated with TNF-α (#2169, 20 ng/ml) for 5 minutes, using Phospho-IκBα (Ser32) (14D4) Rabbit mAb (upper), or IκBα (44D4) Rabbit mAb #4812 (lower).

IκBα (112B2) Mouse mAb (Carboxy-terminal Antigen) - 9247 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 112B2
Western blot analysis of extracts from Hela cells, treated with TNF-α (#2169, 10 ng/ml) for the indicated times, using Phospho-IκBα (Ser32) (14D4) Rabbit mAb #2859 (upper) or IκBα (112B2) Mouse mAb (Carboxy-terminal Antigen) (lower).

IκBα Antibody - 9242 from Cell Signaling Technology

Prices $246.00, $596.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells treated with TNF-α (#2169, 20 ng/ml) for the indicated times, using

IκBα (44D4) Rabbit mAb - 4812 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 44D4
Western blot analysis of extracts from HeLa, NIH/3T3 and PC12 cells, using IκBα (44D4) Rabbit mAb.

IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) - 4814 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone L35A5
Western blot analysis of extracts from THP-1 cells, differentiated with TPA (#9905, 80 nM for 24h) and treated with 1 μg/ml LPS for the indicated times, using Phospho-IκBα (Ser32/36) (5A5) Mouse mAb #9246 (upper) and IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (lower).

Phospho-IkappaB-alpha (Ser32) Antibody - 9241 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells treated with TNF-alpha for the indicated times, using Phospho-IkappaB-alpha (Ser32) Antibody (upper) or IkappaB-alpha Antibody #9242 (lower).

Phospho-IkappaB-alpha (Ser32/36) (5A5) Mouse mAb - 5205 from Cell Signaling Technology

Host Mouse
Clonality Monoclonal
Clone 5A5

IκB-α (C-15) - sc-203 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IκB-α (C-15)-G: sc-203-G. Western blot analysis of IκB-α expression in HeLa (A), Jurkat (B) and A-431 (C) whole cell lysates.

IκB-α (C-21) - sc-371 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IκB-α (C-21): sc-371. Western blot analysis of IκB-α expression in HeLa (A), Jurkat (B), A-431 (C), HL-60 (D), NIH/3T3 (E) and KNRK (F) whole cell lysates.

IκB-α (FL) - sc-847 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IκB-α (FL): sc-847. Western blot analysis of IκB-α expression in A-431 whole cell lysate.

IκB-α (H-4) - sc-1643 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IκB-α (H-4): sc-1643. Western blot analysis of IκB-α expression in NIH/3T3 (A) and KNRK (B) whole cell lysates.

cleaved IκB-α (5D1623) - sc-52900 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

cleaved IκB-α (4H110) - sc-71291 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

p-IκB-α (B-9) - sc-8404 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p-IκB-α. (B-9): sc-8404. Immunofluorescence staining of methanol-fixed, TNFa-treated HeLa cells, showing nuclear localization of activated IκB-α.

p-IκB-α (Ser 32) - sc-7977 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-IκB-α (39A1431) - sc-52943 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
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