NFKBIA

Gene Symbol	NFKBIA
Entrez Gene	4792
Alt Symbol	IKBA, MAD-3, NFKBI
Species	Human
Gene Type	protein-coding
Description	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Other Description	I-kappa-B-alpha|IkappaBalpha|NF-kappa-B inhibitor alpha|ikB-alpha|major histocompatibility complex enhancer-binding protein MAD3|nuclear factor of kappa light chain gene enhancer in B-cells
Swissprots	B2R8L6 P25963
Accessions	AAD14949 AAR29599 CAB65110 CAB65111 CAB65112 CAB65113 CAB65114 CAB65556 CAM91165 CBX47574 EAW65875 P25963 AK311515 AK313421 BAG36213 AY033600 AAK51149 BC002601 AAH02601 BC004983 AAH04983 BT007091 AAP35754 BU737609 M69043 AAA16489 NM_020529 NP_065390
Function	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. {ECO:0000269|PubMed:7479976}.
Subcellular Location	Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. {ECO:0000250}.
Top Pathways	Legionellosis, Herpes simplex infection, Viral carcinogenesis, Influenza A, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence® IκBα siRNA I - 6327 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

IκB-α siRNA (h) - sc-29360 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IκB-α shRNA Plasmid (h) - sc-29360-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IκB-α shRNA (h) Lentiviral Particles - sc-29360-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IκB-α siRNA (h2) - sc-44265 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IκB-α shRNA Plasmid (h2) - sc-44265-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IκB-α shRNA (h2) Lentiviral Particles - sc-44265-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IkB-alpha RNAi - H00004792-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU043721 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15254 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15254 from Sigma-Aldrich Category ZFN Kit

NFKBIA siRNA (Human) - CRH3179 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human NFKBIA (NM_020529.2) - SHH351896 from Creative biogene Category siRNA Species Reactivities Human

NFKBIA shRNA Plasmid (Human) - CHH3179 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

NFKBIA miRNA 3'UTR clone - MiUTR1H-06752 from Creative biogene Species Reactivities Human

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