PPP5C

Gene Symbol PPP5C
Entrez Gene 5536
Alt Symbol PP5, PPP5, PPT
Species Human
Gene Type protein-coding
Description protein phosphatase 5, catalytic subunit
Other Description PP-T|protein phosphatase T|serine/threonine-protein phosphatase 5
Swissprots P53041 Q16722 Q53XV2
Accessions AAD22669 EAW57415 EAW57416 EAW57417 P53041 AB209615 BAD92852 AK094241 AK223222 BAD96942 AK293402 BAG56909 AK293475 BAH11517 AK297095 BAG59608 AK312683 BAG35563 BC000750 AAH00750 BC001831 AAH01831 BC001970 AAH01970 BT007275 AAP35939 DA545760 U25174 AAB60384 X89416 CAA61595 X92121 CAA63089 NM_001204284 NP_001191213 NM_006247 NP_006238
Function Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the an
Subcellular Location Nucleus. Cytoplasm. Membrane. Note=Predominantly nuclear. But also present in the cytoplasm.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:15546861}.
Top Pathways MAPK signaling pathway

PP5 Antibody - 2289 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293, NIH/3T3 and PC12 cells, using PP5 Antibody.

PP5 (F-12) - sc-271817 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PP5 (F-12): sc-271817. Western blot analysis of PP5 expression in HeLa (A), Jurkat (B), PC-12 (C) and A-431 (D) whole cell lysates.

PP5 (H-7) - sc-271816 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PP5 (H-7): sc-271816. Western blot analysis of PP5 expression in HeLa (A), Jurkat (B), PC-12 (C) and A-431 (D) whole cell lysates.

PP5 (H-170) - sc-67039 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PP5 (H-170): sc-67039. Western blot analysis of PP5 expression in non-transfected 293T: sc-117752 (A), mouse PP5 transfected 293T: sc-127371 (B) and PC-12 (C) whole cell lysates.

PP5 (F-8) - sc-271613 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PP5 (F-8): sc-271613. Western blot analysis of PP5 expression in Jurkat (A), A-431 (B) and HeLa (C) whole cell lysates.

PP5 (E-12) - sc-271612 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PP5 (E-12): sc-271612. Western blot analysis of PP5 expression in PC-12 whole cell lysate.

PP5 (C-20) - sc-32588 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PP5 (C-20): sc-32588. Western blot analysis of PP5 expression in PC-12 whole cell lysate (A) and rat brain tissue extract (B).

PP5 (D-19) - sc-32587 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PP5 (D-19): sc-32587. Western blot analysis of PP5 expression in PC-12 (A), HeLa (B) and Jurkat (C) whole cell lysates and rat brain tissue extract (D).

PP5 (3) - sc-136046 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
PP5 (3): sc-136046. Western blot analysis of PP5 expression in rat cerebrum tissue extract.

Anti-PP5 antibody - ab26053 from Abcam

Prices $380.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PP5 antibody (ab26053) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899)Lane 3 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate (ab7909)Lysates/proteins at 20 µg per lane.SecondaryGoat polyclonal to Rabbit IgG (Alexa Fluor® 680) at 1/10000 dilution Performed under reducing conditions.

Anti-PP5 antibody - ab34693 from Abcam

Prices $380.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PP5 antibody (ab34693) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899)Lane 3 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate (ab7909)Lysates/proteins at 20 µg per lane.SecondaryGoat polyclonal to Rabbit IgG (Alexa Fluor® 680) at 1/10000 dilutionPerformed under reducing conditions.

Anti-PP5 antibody - ab71150 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling PPP5 with ab71150 at 1/200 (1µg/ml). Detection: DAB.

Anti-PP5 antibody - ab167313 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-PP5 antibody (ab167313) at 1 µg/ml + Human liver tissue lysate at 50 µg

Anti-PP5 antibody - ab93878 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab93878, at a 1/100 dilution, staining PP5 in formalin fixed, paraffin embedded Human prostate carcinoma tissue by Immunohistochemistry. Detection: DAB staining.

Anti-PP5 antibody [2E12] - ab123919 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E12
All lanes : Anti-PP5 antibody [2E12] (ab123919) at 1/1000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY controlLane 2 : HEK293T cells transfected with pCMV6-ENTRY PP5Lysates/proteins at 5 µg per lane.

Anti-PPP5C Antibody (clone 5G5) - LS-C114690 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5G5
IHC of paraffin-embedded thyroid tissue using anti-PPP5C mouse monoclonal antibody. (Dilution 1:50).

Anti-PPP5C Antibody (aa1-50) - LS-C91599 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-PPP5C Antibody - LS-C26765 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of PP5 specific antibody on A549 and MCF-7 cell lysates.

Anti-PPP5C Antibody - LS-C121290 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PPP5C Antibody (N-Terminus) - LS-C107917 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PPP5C antibody LS-C107917 Western blot of Fetal Thymus lysate.

Anti-PPP5C Antibody (C-Terminus, APC) - LS-C281545 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP5C Antibody (aa445-475) - LS-C101088 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-PPP5C Antibody (C-Terminus, AP) - LS-C281546 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP5C Antibody (C-Terminus, Biotin) - LS-C281547 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP5C Antibody (C-Terminus) - LS-C135395 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PPP5C antibody LS-C135395 Western blot of COL0205 Cell lysate. Antibody concentration 1 ug/ml.
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