PPP5C
| Gene Symbol | PPP5C |
|---|---|
| Entrez Gene | 5536 |
| Alt Symbol | PP5, PPP5, PPT |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein phosphatase 5, catalytic subunit |
| Other Description | PP-T|protein phosphatase T|serine/threonine-protein phosphatase 5 |
| Swissprots | P53041 Q16722 Q53XV2 |
| Accessions | AAD22669 EAW57415 EAW57416 EAW57417 P53041 AB209615 BAD92852 AK094241 AK223222 BAD96942 AK293402 BAG56909 AK293475 BAH11517 AK297095 BAG59608 AK312683 BAG35563 BC000750 AAH00750 BC001831 AAH01831 BC001970 AAH01970 BT007275 AAP35939 DA545760 U25174 AAB60384 X89416 CAA61595 X92121 CAA63089 NM_001204284 NP_001191213 NM_006247 NP_006238 |
| Function | Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the an |
| Subcellular Location | Nucleus. Cytoplasm. Membrane. Note=Predominantly nuclear. But also present in the cytoplasm. |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:15546861}. |
| Top Pathways | MAPK signaling pathway |
PP5 CRISPR/Cas9 KO Plasmid (h) - sc-405979 from Santa Cruz Biotechnology
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PP5 HDR Plasmid (h) - sc-405979-HDR from Santa Cruz Biotechnology
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PP5 Double Nickase Plasmid (h) - sc-405979-NIC from Santa Cruz Biotechnology
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PP5 Double Nickase Plasmid (h2) - sc-405979-NIC-2 from Santa Cruz Biotechnology
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PP5 CRISPR Activation Plasmid (h) - sc-405979-ACT from Santa Cruz Biotechnology
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PP5 CRISPR Activation Plasmid (h2) - sc-405979-ACT-2 from Santa Cruz Biotechnology
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PP5 Lentiviral Activation Particles (h) - sc-405979-LAC from Santa Cruz Biotechnology
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PP5 Lentiviral Activation Particles (h2) - sc-405979-LAC-2 from Santa Cruz Biotechnology
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PP5 siRNA (h) - sc-44602 from Santa Cruz Biotechnology
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PP5 shRNA Plasmid (h) - sc-44602-SH from Santa Cruz Biotechnology
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PP5 shRNA (h) Lentiviral Particles - sc-44602-V from Santa Cruz Biotechnology
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PP5 RNAi - H00005536-R02 from Novus Biologicals
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MISSION® esiRNA - EHU023901 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0676 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0677 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0678 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17314 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17314 from Sigma-Aldrich
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PPP5C siRNA (Human) - CRH3715 from Cohesion Biosciences
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shRNA set against Human PPP5C (NM_006247.3) - SHH381640 from Creative biogene
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Human PPP5C siRNA - orb264217 from Biorbyt
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PPP5C shRNA Plasmid (Human) - CHH3715 from Cohesion Biosciences
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PPP5C miRNA 3'UTR clone - MiUTR3H-03544 from Creative biogene
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