PPP5C

Gene Symbol PPP5C
Entrez Gene 5536
Alt Symbol PP5, PPP5, PPT
Species Human
Gene Type protein-coding
Description protein phosphatase 5, catalytic subunit
Other Description PP-T|protein phosphatase T|serine/threonine-protein phosphatase 5
Swissprots P53041 Q16722 Q53XV2
Accessions AAD22669 EAW57415 EAW57416 EAW57417 P53041 AB209615 BAD92852 AK094241 AK223222 BAD96942 AK293402 BAG56909 AK293475 BAH11517 AK297095 BAG59608 AK312683 BAG35563 BC000750 AAH00750 BC001831 AAH01831 BC001970 AAH01970 BT007275 AAP35939 DA545760 U25174 AAB60384 X89416 CAA61595 X92121 CAA63089 NM_001204284 NP_001191213 NM_006247 NP_006238
Function Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the an
Subcellular Location Nucleus. Cytoplasm. Membrane. Note=Predominantly nuclear. But also present in the cytoplasm.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:15546861}.
Top Pathways MAPK signaling pathway

PPP5C 293T Cell Transient Overexpression Lysate(Denatured) - H00005536-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

PPP5C 293 Cell Lysate - 407829 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

PP5 Overexpression Lysate (Denatured) - H00005536-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
Lane 1: PPP5C transfected lysate (56.9 KDa) Lane 2: Non-transfected lysate.

PP5 Overexpression Lysate (Native) - NBL1-14711 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: PP5 Overexpression Lysate (Adult Normal) [NBL1-14711] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PP5.

PPP5C Over-expression Lysate Product - GWB-9ADE00 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human PPP5C Knockdown Stable Cell Line - CSC-DC012294 from Creative biogene

Category Cell Line
Species Human

PPP5C KO Cell Lysate-HEK293T - CLKO-0802 from Creative biogene

Category Cell Lysate
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