PPP5C

Gene Symbol	PPP5C
Entrez Gene	5536
Alt Symbol	PP5, PPP5, PPT
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 5, catalytic subunit
Other Description	PP-T|protein phosphatase T|serine/threonine-protein phosphatase 5
Swissprots	P53041 Q16722 Q53XV2
Accessions	AAD22669 EAW57415 EAW57416 EAW57417 P53041 AB209615 BAD92852 AK094241 AK223222 BAD96942 AK293402 BAG56909 AK293475 BAH11517 AK297095 BAG59608 AK312683 BAG35563 BC000750 AAH00750 BC001831 AAH01831 BC001970 AAH01970 BT007275 AAP35939 DA545760 U25174 AAB60384 X89416 CAA61595 X92121 CAA63089 NM_001204284 NP_001191213 NM_006247 NP_006238
Function	Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the an
Subcellular Location	Nucleus. Cytoplasm. Membrane. Note=Predominantly nuclear. But also present in the cytoplasm.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:15546861}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PPP5C Gene cDNA Clone - orb144833 from Biorbyt Prices $366.00 Sizes 10 μg Species Human

PPP5C - MBS1275514 from MyBioSource Species Human Accession BC001970

Human PPP5C Gene ORF cDNA clone in cloning vector - HG13864-G from Sino Biological Species Human

Human PPP5C Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13864-CM from Sino Biological Species Human

Human PPP5C Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG13864-ANR from Sino Biological Species Human

Human PPP5C Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG13864-ANG from Sino Biological Species Human

Human PPP5C Gene ORF cDNA clone expression plasmid, N-His tag - HG13864-NH from Sino Biological Species Human

Human PPP5C Gene ORF cDNA clone expression plasmid, C-HA tag - HG13864-CY from Sino Biological Species Human

Human PPP5C Gene ORF cDNA clone expression plasmid - HG13864-UT from Sino Biological Species Human

Human PPP5C Gene ORF cDNA clone expression plasmid, C-His tag - HG13864-CH from Sino Biological Species Human

Human PPP5C Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13864-NF from Sino Biological Species Human

Human PPP5C Gene ORF cDNA clone expression plasmid, N-HA tag - HG13864-NY from Sino Biological Species Human

Human PPP5C Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13864-NM from Sino Biological Species Human

Human PPP5C Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13864-CF from Sino Biological Species Human

Human PPP5C Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13864-ACG from Sino Biological Species Human

human PPP5C ORF clone (NM_001204284.1) - CDCH067128 from Creative biogene Species Human

Human PPP5C ORF Clone (BC001970) - CDCS409614 from Creative biogene Species Human Accession P53041

Human PPP5C ORF clone (BC001970) - CDCB159593 from Creative biogene Species Human

Human PP5/PPP5C (NP_006238) VersaClone cDNA - RDC1983 from R&D Systems Prices $199.00 Sizes 10 µg Species Human

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