PPP5C

Gene Symbol PPP5C
Entrez Gene 5536
Alt Symbol PP5, PPP5, PPT
Species Human
Gene Type protein-coding
Description protein phosphatase 5, catalytic subunit
Other Description PP-T|protein phosphatase T|serine/threonine-protein phosphatase 5
Swissprots P53041 Q16722 Q53XV2
Accessions AAD22669 EAW57415 EAW57416 EAW57417 P53041 AB209615 BAD92852 AK094241 AK223222 BAD96942 AK293402 BAG56909 AK293475 BAH11517 AK297095 BAG59608 AK312683 BAG35563 BC000750 AAH00750 BC001831 AAH01831 BC001970 AAH01970 BT007275 AAP35939 DA545760 U25174 AAB60384 X89416 CAA61595 X92121 CAA63089 NM_001204284 NP_001191213 NM_006247 NP_006238
Function Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the an
Subcellular Location Nucleus. Cytoplasm. Membrane. Note=Predominantly nuclear. But also present in the cytoplasm.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:15546861}.
Top Pathways MAPK signaling pathway

Rabbit anti-PPP5C Antibody, Affinity Purified - PLA0156 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunohistochemistry</B><BR/>Rabbit Anti-PPP5C Antibody, Affinity Purified: <B>Cat. No. PLA0156</B>: Detection of Human PPP5C by Immunohistochemistry. Sample: FFPE section of Human prostate carcinoma. Antibody: Affinity purified Rabbit Anti-PPP5C (<B>Cat. No. PLA0156</B>) used at a dilution of 1:200 (1 μg/mL). Detection: DAB

PPP5C (Human) IP-WB Antibody Pair - H00005536-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

PPP5C (Human) Matched Antibody Pair - H00005536-AP22 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

protein phosphatase 5, catalytic subunit, ELISA Kit - MBS9321046 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human PPP5C ELISA Kit - E031759 from Biobool

Category ELISA Kit
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