PPP5C

Gene Symbol	PPP5C
Entrez Gene	5536
Alt Symbol	PP5, PPP5, PPT
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 5, catalytic subunit
Other Description	PP-T|protein phosphatase T|serine/threonine-protein phosphatase 5
Swissprots	P53041 Q16722 Q53XV2
Accessions	AAD22669 EAW57415 EAW57416 EAW57417 P53041 AB209615 BAD92852 AK094241 AK223222 BAD96942 AK293402 BAG56909 AK293475 BAH11517 AK297095 BAG59608 AK312683 BAG35563 BC000750 AAH00750 BC001831 AAH01831 BC001970 AAH01970 BT007275 AAP35939 DA545760 U25174 AAB60384 X89416 CAA61595 X92121 CAA63089 NM_001204284 NP_001191213 NM_006247 NP_006238
Function	Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the an
Subcellular Location	Nucleus. Cytoplasm. Membrane. Note=Predominantly nuclear. But also present in the cytoplasm.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:15546861}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PP5 full length protein - ab91714 from Abcam Category Protein Source E. coli Species Human

Human PP5 peptide - ab27751 from Abcam Category Peptide

Human PP5 peptide - ab27752 from Abcam Category Peptide

PPP5C Antibody Blocking Peptide - LS-E20624 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP5C Antibody Blocking Peptide - LS-E20625 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP5C Antibody Blocking Peptide - LS-E9600 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP5C Antibody Blocking Peptide - LS-E9601 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PP5 Protein - H00005536-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PP5 Peptide - P3330 from Novus Biologicals Category Peptide Species Human

PPP5C-Antibody-S460-Blocking-peptide - BP11664a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PPP5C-Antibody-C-term-Blocking-Peptide - BP14552b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PP5-Antibody-C-term-Blocking-peptide - BP8476b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PPP5C Blocking Peptide - 33R-1130 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PPP5C Blocking Peptide - 33R-5701 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PPP5C - H00005536-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PPP5C - H00005536-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PPP5C fusion protein - Ag2288 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Protein Phosphatase 5, Catalytic Subunit - PPP5C-177H from Creative Biomart Category Protein Source E.Coli .

Recombinant Human PPP5C, Catalytic Domain - PPP5C-178H from Creative Biomart Category Protein Source E.Coli .

Recombinant Human PPP5C, His-tagged - PPP5C-27638TH from Creative Biomart Category Protein Source E. coli

Recombinant Human PPP5C, GST-tagged - PPP5C-1927H from Creative Biomart Category Protein Source E.coli Species Human

PP5, active - 14-778 from EMD Millipore Prices $318.00 Sizes 10 µg also available in 250μg size as catalog # 14-778m and in bulk as catalog # 14-778-k. Source N-terminal GST-tagged, recombinant, full length, human PP5, expressed in E. coli cells.

PP5, active - 14-778M from EMD Millipore Prices $2,544.00 Sizes 250 µg also available in 10μg size as catalog # 14-778 and in 250 μg as catalog # 14-778m. Source N-terminal GST-tagged, recombinant, full length, human PP5, expressed in E. coli cells.

Recombinant Human Serine/threonine-protein phosphatase 5(PPP5C) - CSB-YP018582HU CSB-EP018582HU CSB-BP018582HU CSB-MP018582HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PP5 Protein - NBP2-38812PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

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