S100B

Gene Symbol	S100B
Entrez Gene	6285
Alt Symbol	NEF, S100, S100-B, S100beta
Species	Human
Gene Type	protein-coding
Description	S100 calcium binding protein B
Other Description	S-100 calcium-binding protein, beta chain|S-100 protein subunit beta|S100 calcium-binding protein, beta (neural)|protein S100-B
Swissprots	P04271 D3DSN6
Accessions	AAA60367 EAX09267 EAX09268 EAX09269 EAX09270 P04271 AA310307 BC001766 AAH01766 BC041935 CR542123 CAG46920 DQ892491 ABM83417 EB386131 EU176695 ABW03496 NM_006272 NP_006263
Function	Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. {ECO:0000269|PubMed:20351179, ECO:0000269|PubMed:22399290}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9925766}. Nucleus {ECO:0000269|PubMed:9925766}.
Tissue Specificity	Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human S100 beta full length protein - ab200489 from Abcam Category Protein Prices $500.00 Sizes 100 µg Source E. coli Species Human

Cow S100 beta full length protein - ab198633 from Abcam Category Protein Prices $286.00 Sizes 100 µg Source Native Species Bovine

HIV1 Nef full length protein - ab90462 from Abcam Category Protein Prices $297.00 Sizes 50 µg Source E. coli

HIV1 Nef full length protein - ab63996 from Abcam Category Protein Prices $235.00 Sizes 20 µg Source E. coli

HIV1 Nef full length protein - ab58914 from Abcam Category Protein Prices $280.00 Sizes 50 µg Source E. coli

HIV1 Nef protein fragment - ab49060 from Abcam Category Protein Prices $192.00 Sizes 100 µg Source E. coli

Human S100 beta full length protein - ab82734 from Abcam Category Protein Source E. coli Species Human

Human S100 beta full length protein - ab55570 from Abcam Category Protein Source E. coli Species Human

Rat S100 beta peptide - ab41547 from Abcam Category Peptide

S100 beta peptide - ab30380 from Abcam Category Peptide

S100B / S100 Beta Antibody Blocking Peptide - LS-E3727 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

S100B / S100 Beta Antibody Blocking Peptide - LS-E11984 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Primate S100B Protein - NBP2-35319 from Novus Biologicals Category Protein Prices $69.00, $169.00, $2,569.00 Sizes 2 µg, 10 µg, 1 mg Source E. coli

Recombinant Human S100B Protein - H00006285-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human S100B Protein - H00006285-Q01 from Novus Biologicals Category Protein Prices $529.00 Sizes 25 µg Source Wheat Germ Species Human

Recombinant Human S100B Protein - NBP1-50844 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

S100BS-100-Antibody-Center-Blocking-Peptide - BP14936c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

S100 beta Protein - GTX110715-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

S100A1 Protein - GTX109262-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

Recombinant Human S100B, CF - 1820-SB-050 from R&D Systems Category Protein Source E. coli-derived, Met1-Glu92

Recombinant human protein S100-B (OPCA00885) - OPCA00885 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human Brain S-100b Protein (OPMA04311) - OPMA04311 from Aviva Systems Biology Category Protein Prices $2,415.00 Sizes 1 mg Source Human Brain Tissue Species Human

S100B Protein (OPPA01222) - OPPA01222 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

S100B Protein (OPPA02092) - OPPA02092 from Aviva Systems Biology Category Protein Prices $315.00 Sizes 2 µg Source E. Coli

Human S-100 Protein - orb79686 from Biorbyt Category Protein Prices $527.00, $859.00, $1,199.00 Sizes 100 µg, 500 µg, 1 mg Species Human

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