Gene Symbol | S100B |
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Entrez Gene | 6285 |
Alt Symbol | NEF, S100, S100-B, S100beta |
Species | Human |
Gene Type | protein-coding |
Description | S100 calcium binding protein B |
Other Description | S-100 calcium-binding protein, beta chain|S-100 protein subunit beta|S100 calcium-binding protein, beta (neural)|protein S100-B |
Swissprots | P04271 D3DSN6 |
Accessions | AAA60367 EAX09267 EAX09268 EAX09269 EAX09270 P04271 AA310307 BC001766 AAH01766 BC041935 CR542123 CAG46920 DQ892491 ABM83417 EB386131 EU176695 ABW03496 NM_006272 NP_006263 |
Function | Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. {ECO:0000269|PubMed:20351179, ECO:0000269|PubMed:22399290}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:9925766}. Nucleus {ECO:0000269|PubMed:9925766}. |
Tissue Specificity | Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. |
S-100 β chain siRNA (h) - sc-43356 from Santa Cruz Biotechnology
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S-100 β chain shRNA Plasmid (h) - sc-43356-SH from Santa Cruz Biotechnology
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S-100 β chain shRNA (h) Lentiviral Particles - sc-43356-V from Santa Cruz Biotechnology
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S100B RNAi - H00006285-R01 from Novus Biologicals
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MISSION® esiRNA - EHU007051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18796 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18796 from Sigma-Aldrich
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S100B siRNA (Human) - CRH4233 from Cohesion Biosciences
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S100B - MBS8211831 from MyBioSource
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shRNA set against Human S100B (NM_006272.2) - SHH401244 from Creative biogene
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shRNA set against Human S100B(NM_006272.2) - SHR203176 from Creative biogene
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Human S100B siRNA - orb264735 from Biorbyt
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S100B shRNA Plasmid (Human) - CHH4233 from Cohesion Biosciences
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S100B miRNA 3'UTR clone - MiUTR1H-09117 from Creative biogene
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