| Gene Symbol |
S100B
|
| Entrez Gene |
6285
|
| Alt Symbol |
NEF, S100, S100-B, S100beta
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
S100 calcium binding protein B
|
| Other Description |
S-100 calcium-binding protein, beta chain|S-100 protein subunit beta|S100 calcium-binding protein, beta (neural)|protein S100-B
|
| Swissprots |
P04271 D3DSN6
|
| Accessions |
AAA60367 EAX09267 EAX09268 EAX09269 EAX09270 P04271 AA310307 BC001766 AAH01766 BC041935 CR542123 CAG46920 DQ892491 ABM83417 EB386131 EU176695 ABW03496 NM_006272 NP_006263
|
| Function |
Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. {ECO:0000269|PubMed:20351179, ECO:0000269|PubMed:22399290}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:9925766}. Nucleus {ECO:0000269|PubMed:9925766}.
|
| Tissue Specificity |
Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.
|
