DOT1L

Gene Symbol DOT1L
Entrez Gene 84444
Alt Symbol DOT1, KMT4
Species Human
Gene Type protein-coding
Description DOT1-like histone H3K79 methyltransferase
Other Description DOT1-like protein|DOT1-like, histone H3 methyltransferase|H3-K79-HMTase|histone H3-K79 methyltransferase|histone methyltransferase DOT1L|histone-lysine N-methyltransferase, H3 lysine-79 specific|lysine N-methyltransferase 4
Swissprots O60379 Q8TEK3 Q96JL1
Accessions AAC08316 EAW69408 EAW69409 EAW69410 EAW69411 Q8TEK3 AB058717 BAB47443 AF509504 AAM88322 AK074120 BAB84946 AK095280 AL080221 BC021037 BC032803 BC156103 AAI56104 DQ595517 XM_005259659 XP_005259716 XM_005259660 XP_005259717 XM_006722923 XP_006722986 XM_011528359 XP_011526661 XM_011528360 XP_011526662 XM_011528361 XP_011526663 NM_032482 NP_115871
Function Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
Subcellular Location Nucleus {ECO:0000269|PubMed:15851025}.
Top Pathways Lysine degradation, Transcriptional misregulation in cancer

DOT1L1 (C-3) - sc-390879 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DOT1L1 (C-3): sc-390879. Western blot analysis of DOT1L1 expression in non-transfected: sc-117752 (A) and mouse DOT1L1 transfected: sc-178530 (B) 293T whole cell lysates.

DOT1L1 (C-19) - sc-69562 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DOT1L1 (C-19): sc-69562. Western blot analysis of DOT1L1 expression in non-transfected: sc-117752 (A) and mouse DOT1L1 transfected: sc-178530 (B) 293T whole cell lysates.

DOT1L1 (E-5) - sc-374317 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DOT1L1 (E-5): sc-374317. Western blot analysis of DOT1L1 expression in non-transfected: sc-117752 (A) and mouse DOT1L1 transfected: sc-178530 (B) 293T whole cell lysates.

DOT1L1 (H-300) - sc-292233 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DOT1L1 (H-300): sc-292233. Western blot analysis of DOT1L1 expression in non-transfected: sc-117752 (A) and mouse DOT1L1 transfected: sc-178530 (B) 293T whole cell lysates.

Anti-KMT4 / Dot1L antibody - ab64077 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lanes 1 - 2 : Anti-KMT4 / Dot1L antibody (ab64077) at 5 µg/ml (1% Milk Block)Lanes 3 - 4 : Anti-KMT4 / Dot1L antibody (ab64077) at 2 µg/ml (1% Milk Block)Lane 1 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lane 2 : Liver (Mouse) Tissue LysateLane 3 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lane 4 : Liver (Mouse) Tissue LysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-KMT4 / Dot1L antibody - ab72454 from Abcam

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung carcinoma tissue labelling KMT4 / Dot1L with ab72454 at 1/200 (1µg/ml). Detection: DAB.

Anti-KMT4 / Dot1L antibody - ab95128 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab95128, at 1/100 dilution, staining KMT4 / Dot1L in formalin-fixed, paraffin-embedded Human colon carcinoma by Immunohistochemistry, using DAB staining.

Anti-KMT4 / Dot1L antibody - ab200937 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-KMT4 / Dot1L antibody [6E7] - ab180483 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6E7
All lanes : Anti-KMT4 / Dot1L antibody [6E7] (ab180483) at 1/2000 dilutionLane 1 : Lysate from HEK293T cells transfected with pCMV6-ENTRY control cDNALane 2 : Lysate from HEK293T cells transfected with pCMV6-ENTRY KMT4 / Dot1L cDNALysates/proteins at 5 µg per lane.

Anti-KMT4 / Dot1L antibody [EPR7317(2)] - ab157199 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7317(2)
All lanes : Anti-KMT4 / Dot1L antibody [EPR7317(2)] (ab157199) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : HeLa cell lysateLysates/proteins at 10 µg per lane.

Anti-KMT4 / Dot1L antibody - C-terminal - ab176363 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-KMT4 / Dot1L antibody - C-terminal (ab176363) at 1/1000 dilution + Mouse thymus tissue lysate

Anti-DOT1L / DOT1 Antibody (aa1000-1050) - LS-C287786 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human DOT1L by Immunohistochemistry. Sample: FFPE section of human lung carcinoma. Antibody: Affinity purified rabbit anti-DOT1L used at a dilution of 1:200 (1 Detection: DAB.

Anti-DOT1L / DOT1 Antibody (aa1-434, clone 1F6) - LS-C338560 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F6
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOT1L (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DOT1L.

Anti-DOT1L / DOT1 Antibody (aa1-434, clone 1F8) - LS-C336581 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F8
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOT1L (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DOT1L.

Anti-DOT1L / DOT1 Antibody (aa1-434, clone 2B10) - LS-C338557 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOT1L (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DOT1L.

Anti-DOT1L / DOT1 Antibody (aa1008-1424, clone 8A11) - LS-C336654 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8A11
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOT1L (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DOT1L.

Anti-DOT1L / DOT1 Antibody (aa1008-1424, clone 3E9) - LS-C336656 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3E9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOT1L (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DOT1L.

Anti-DOT1L / DOT1 Antibody (aa1008-1424, clone 7H6) - LS-C336664 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7H6
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOT1L (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DOT1L.

Anti-DOT1L / DOT1 Antibody (aa1008-1424, clone 11H2) - LS-C336657 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 11H2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOT1L (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DOT1L.

Anti-DOT1L / DOT1 Antibody (aa1-434, clone 5D12) - LS-C338559 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5D12
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOT1L (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DOT1L.

Anti-DOT1L / DOT1 Antibody (aa1000-1050) - LS-C286711 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human DOT1L by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-DOT1L used at a dilution of 1:100. Epitope Retrieval Buffer-High pH (IHC-101J) was substituted for Epitope Retrieval Buffer-Reduced pH.

Anti-DOT1L / DOT1 Antibody (aa1-434, clone 1D8) - LS-C338561 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D8
IHC of paraffin-embedded Human lymphoma tissue using anti-DOT1L mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-DOT1L / DOT1 Antibody (aa1008-1424, clone 6E7) - LS-C336653 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6E7
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-DOT1L mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-DOT1L / DOT1 Antibody (aa1008-1424, clone 1F1D4) - LS-C336659 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F1D4
IHC of paraffin-embedded Human endometrium tissue using anti-DOT1L mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-DOT1L / DOT1 Antibody (aa1000-1050) - LS-C64992 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal
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