| Gene Symbol |
DOT1L
|
| Entrez Gene |
84444
|
| Alt Symbol |
DOT1, KMT4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DOT1-like histone H3K79 methyltransferase
|
| Other Description |
DOT1-like protein|DOT1-like, histone H3 methyltransferase|H3-K79-HMTase|histone H3-K79 methyltransferase|histone methyltransferase DOT1L|histone-lysine N-methyltransferase, H3 lysine-79 specific|lysine N-methyltransferase 4
|
| Swissprots |
O60379 Q8TEK3 Q96JL1
|
| Accessions |
AAC08316 EAW69408 EAW69409 EAW69410 EAW69411 Q8TEK3 AB058717 BAB47443 AF509504 AAM88322 AK074120 BAB84946 AK095280 AL080221 BC021037 BC032803 BC156103 AAI56104 DQ595517 XM_005259659 XP_005259716 XM_005259660 XP_005259717 XM_006722923 XP_006722986 XM_011528359 XP_011526661 XM_011528360 XP_011526662 XM_011528361 XP_011526663 NM_032482 NP_115871
|
| Function |
Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15851025}.
|
| Top Pathways |
Lysine degradation, Transcriptional misregulation in cancer
|
![Western Blot: Dot1L Overexpression Lysate (Adult Normal) [NBL1-09984] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Dot1L.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2437_Dot1L%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09984-img0002.jpg)