DOT1L

Gene Symbol	DOT1L
Entrez Gene	84444
Alt Symbol	DOT1, KMT4
Species	Human
Gene Type	protein-coding
Description	DOT1-like histone H3K79 methyltransferase
Other Description	DOT1-like protein|DOT1-like, histone H3 methyltransferase|H3-K79-HMTase|histone H3-K79 methyltransferase|histone methyltransferase DOT1L|histone-lysine N-methyltransferase, H3 lysine-79 specific|lysine N-methyltransferase 4
Swissprots	O60379 Q8TEK3 Q96JL1
Accessions	AAC08316 EAW69408 EAW69409 EAW69410 EAW69411 Q8TEK3 AB058717 BAB47443 AF509504 AAM88322 AK074120 BAB84946 AK095280 AL080221 BC021037 BC032803 BC156103 AAI56104 DQ595517 XM_005259659 XP_005259716 XM_005259660 XP_005259717 XM_006722923 XP_006722986 XM_011528359 XP_011526661 XM_011528360 XP_011526662 XM_011528361 XP_011526663 NM_032482 NP_115871
Function	Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15851025}.
Top Pathways	Lysine degradation, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KMT4 / Dot1L peptide - ab71337 from Abcam Category Peptide

Human KMT4 / Dot1L protein fragment - ab176960 from Abcam Category Protein Source E. coli Species Human

Human KMT4 / Dot1L protein fragment - ab80254 from Abcam Category Protein Source E. coli Species Human

Recombinant Human DOT1L Protein - H00084444-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Human DOT1L protein - orb83968 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source E. coli Species Human

DOT1L - H00084444-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DOT1L - H00084444-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant DOT1L (1-416) protein - 31474 from ActiveMotif Category Protein Prices $395.00, $2,900.00 Sizes 50 µg, 1 mg Source E. coli Species Human

Recombinant Human DOT1L, GST-tagged - DOT1L-514H from Creative Biomart Category Protein Source E.Coli .

Recombinant Human DOT1L, None tagged - DOT1L-767H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human DOT1L - DOT1L-27742TH from Creative Biomart Category Protein Source E. coli

Recombinant Human DOT1L, GST-tagged - DOT1L-657H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human DOT1L, GST-tagged - DOT1L-658H from Creative Biomart Category Protein Source E. coli Species Human

DOT1L - PN201502 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source E.coli Species Human

Human DOT1L / KMT4 Protein - 11552-HNCE-20 from Sino Biological Category Protein Source E. coli Species Human

Recombinant Human Histone-lysine N-methyltransferase, H3 lysine-79 specific(DOT1L) ,partial - CSB-YP848418HU CSB-EP848418HU CSB-BP848418HU CSB-MP848418HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DOT1L (2- 416 aa), Human recombinant - 7666-25 from Biovision Category Protein Prices $225.00 Sizes 25 μg Source E. coli Species Human

DOT1L Protein - abx163431 from Abbexa Category Protein Species Human, Mouse, Rat

Recombinant Human DOT1L / KMT4 Protein - PKSH031093 from Elabscience Category Protein Source E. coli Species Human

Recombinant Human DOT1L protein, GST-tagged - DOT1L-75H from Creative Biomart Category Protein Source E. coli Species Human

KMT4--Dot1L-Antibody-C-Term-Blocking-peptide - BP1198b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KMT4--Dot1L-Antibody-N-Term-Blocking-peptide - BP1198a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DOT1L Peptide, Human - M34GP04496H from Creative Peptides Category Peptide Source Synthetic. Species Human

DOT1L (2- 416 aa), Human recombinant - 7666 from Biovision Category Protein Prices $225.00 Sizes 25 μg Source E. coli Species Human

Human DOT1L / KMT4 Protein - 11552-HNCE from ABclonal Category Protein Prices $138.00, $298.00 Sizes 20 µg, 50 µg Source E. coli Species Human

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