DOT1L

Gene Symbol DOT1L
Entrez Gene 84444
Alt Symbol DOT1, KMT4
Species Human
Gene Type protein-coding
Description DOT1-like histone H3K79 methyltransferase
Other Description DOT1-like protein|DOT1-like, histone H3 methyltransferase|H3-K79-HMTase|histone H3-K79 methyltransferase|histone methyltransferase DOT1L|histone-lysine N-methyltransferase, H3 lysine-79 specific|lysine N-methyltransferase 4
Swissprots O60379 Q8TEK3 Q96JL1
Accessions AAC08316 EAW69408 EAW69409 EAW69410 EAW69411 Q8TEK3 AB058717 BAB47443 AF509504 AAM88322 AK074120 BAB84946 AK095280 AL080221 BC021037 BC032803 BC156103 AAI56104 DQ595517 XM_005259659 XP_005259716 XM_005259660 XP_005259717 XM_006722923 XP_006722986 XM_011528359 XP_011526661 XM_011528360 XP_011526662 XM_011528361 XP_011526663 NM_032482 NP_115871
Function Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
Subcellular Location Nucleus {ECO:0000269|PubMed:15851025}.
Top Pathways Lysine degradation, Transcriptional misregulation in cancer

DOT1L1 CRISPR/Cas9 KO Plasmid (h) - sc-403286 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DOT1L1 HDR Plasmid (h) - sc-403286-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DOT1L1 Double Nickase Plasmid (h) - sc-403286-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DOT1L1 Double Nickase Plasmid (h2) - sc-403286-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DOT1L1 CRISPR Activation Plasmid (h) - sc-403286-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DOT1L1 CRISPR Activation Plasmid (h2) - sc-403286-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DOT1L1 Lentiviral Activation Particles (h) - sc-403286-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DOT1L1 Lentiviral Activation Particles (h2) - sc-403286-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DOT1L1 siRNA (h) - sc-77174 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DOT1L1 shRNA Plasmid (h) - sc-77174-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DOT1L1 shRNA (h) Lentiviral Particles - sc-77174-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DOT1L RNAi - H00084444-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU092391 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7440 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7440 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01025 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01025

DOT1L siRNA (Human) - CRJ3476 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DOT1L - MBS8212063 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DOT1L (NM_032482.2) - SHH280425 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human DOT1L(NM_032482.2) - SHH014033 from Creative biogene

Category siRNA
Species Reactivities Human

Human DOT1L siRNA - orb273977 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DOT1L shRNA Plasmid (Human) - CHJ3476 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DOT1L miRNA 3'UTR clone - MiUTR1H-02961 from Creative biogene

Species Reactivities Human
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