DOT1L

Gene Symbol	DOT1L
Entrez Gene	84444
Alt Symbol	DOT1, KMT4
Species	Human
Gene Type	protein-coding
Description	DOT1-like histone H3K79 methyltransferase
Other Description	DOT1-like protein|DOT1-like, histone H3 methyltransferase|H3-K79-HMTase|histone H3-K79 methyltransferase|histone methyltransferase DOT1L|histone-lysine N-methyltransferase, H3 lysine-79 specific|lysine N-methyltransferase 4
Swissprots	O60379 Q8TEK3 Q96JL1
Accessions	AAC08316 EAW69408 EAW69409 EAW69410 EAW69411 Q8TEK3 AB058717 BAB47443 AF509504 AAM88322 AK074120 BAB84946 AK095280 AL080221 BC021037 BC032803 BC156103 AAI56104 DQ595517 XM_005259659 XP_005259716 XM_005259660 XP_005259717 XM_006722923 XP_006722986 XM_011528359 XP_011526661 XM_011528360 XP_011526662 XM_011528361 XP_011526663 NM_032482 NP_115871
Function	Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15851025}.
Top Pathways	Lysine degradation, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DOT1-like, histone H3 methyltransferase (S. cerevisiae) , ELISA Kit - MBS9342121 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml. Range 0.625 ng/ml - 20 ng/ml.

ELISA Kit for DOT1 Like, Histone H3 Methyltransferase (DOT1L) - SEL444Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for DOT1 Like, Histone H3 Methyltransferase (DOT1L) - SEL444Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.063ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for DOT1 Like, Histone H3 Methyltransferase (DOT1L) - SEL444Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human DOT1L / DOT1 ELISA Kit (Sandwich ELISA) - LS-F25586 from LifeSpan Bioscience Category ELISA Kit Prices $850.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Mouse DOT1L / DOT1 ELISA Kit (Sandwich ELISA) - LS-F25587 from LifeSpan Bioscience Category ELISA Kit Prices $880.00 Sizes 1 plate Sensitivity 0.063 ng/ml Range 0.156-10 ng/ml

Human DOT1L ELISA Kit - E012330 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of DOT1L is typically less than 0.058ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding tw

DOT1L ELISA Kit (Human) (OKCD02046) - OKCD02046 from Aviva Systems Biology Category ELISA Kit Prices $585.00 Sizes 96 wells Sensitivity < 0.058 ng/mL Range 0.156 - 10 ng/mL

Human Histone-lysine N-methyltransferase, H3 lysine-79 specific (DOT1L) ELISA Kit - AE46758HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.059 ng/mL Range 0.156-10 ng/mL

Histone-Lysine N-Methyltransferase, H3 Lysine-79 Specific (DOT1L), ELISA Kit - MBS9372579 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase, H3 Lysine-79 Specific (DOT1L), ELISA Kit - MBS9378533 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase, H3 Lysine-79 Specific (DOT1L), ELISA Kit - MBS9371831 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase, H3 Lysine-79 Specific (DOT1L), ELISA Kit - MBS9376210 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase, H3 Lysine-79 Specific (DOT1L), ELISA Kit - MBS9376884 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase, H3 Lysine-79 Specific (DOT1L), ELISA Kit - MBS9380041 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase, H3 Lysine-79 Specific (DOT1L), ELISA Kit - MBS9381266 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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