SOST

Gene Symbol SOST
Entrez Gene 50964
Alt Symbol CDD, SOST1, VBCH
Species Human
Gene Type protein-coding
Description sclerostin
Other Description -
Swissprots Q9BQB4 Q495N9
Accessions AAK13451 CAI46877 CEF39438 EAW51669 Q9BQB4 AF170491 AAQ13601 AF184211 AAQ13694 AF326739 AAK13454 AF331844 AAK16158 AY358203 AAQ88570 AY358627 AAQ88990 BC101086 AAI01087 BC101087 AAI01088 BC101088 AAI01089 BC101089 AAI01090 NM_025237 NP_079513
Function Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. {ECO:0000269|PubMed:15908424}.
Subcellular Location Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20551380}.
Tissue Specificity Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level). {ECO:0000269|PubMed:20551380}.
Top Pathways Wnt signaling pathway

Sclerostin (C-17) - sc-324954 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Sclerostin (N-22) - sc-130258 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Sclerostin (N-22): sc-130258. Immunoperoxidase staining of formalin fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic staining.

Sclerostin (T-14) - sc-324952 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Sclerostin antibody - ab63097 from Abcam

Prices $394.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Sclerostin antibody (ab63097) at 1/1000 dilution + HeLa cell lysate at 35 µgSecondaryHRP-conjugated goat anti-rabbit IgG (H+L) at 1/5000 dilution

Anti-Sclerostin antibody - ab85799 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Sclerostin antibody (ab85799) at 1 µg/ml + Bone (Human) Tissue Lysate - tumor tissue (ab29359) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Sclerostin antibody - ab75914 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ab75914. A peroxidase-conjugated secondary antibody was then used, followed by DAB staining.

Anti-Sclerostin antibody [MM0556-9N13] - ab89733 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0556-9N13

Anti-Sclerostin antibody - C-terminal - ab194940 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human kidney tissue labeling Sclerostin with ab194940 at 4 μg/mL using HRP detection.

Anti-SOST / Sclerostin Antibody (aa38-87) IHC-plus™ - LS-B11640 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-SOST / Sclerostin Antibody (C-Terminus) - LS-C39024 from LifeSpan Bioscience

Prices $415.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SOST / Sclerostin Antibody (aa141-171, AP) - LS-C269959 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOST / Sclerostin Antibody (aa141-171, APC) - LS-C269960 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOST / Sclerostin Antibody (aa141-171, FITC) - LS-C269961 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOST / Sclerostin Antibody (aa141-171, Biotin) - LS-C269962 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOST / Sclerostin Antibody (aa141-171, Azide-free, HRP) - LS-C269963 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOST / Sclerostin Antibody (aa141-171, PE) - LS-C269964 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOST / Sclerostin Antibody (aa38-66) - LS-C159063 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SOST Antibody western blot of mouse liver tissue lysates (35 ug/lane). The SOST antibody detected the SOST protein (arrow).

Anti-SOST / Sclerostin Antibody (aa38-66, AP) - LS-C269965 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOST / Sclerostin Antibody (aa134-163) - LS-C100509 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with SOST antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-SOST / Sclerostin Antibody (aa38-66, Biotin) - LS-C269967 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOST / Sclerostin Antibody (aa38-66, APC) - LS-C269966 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOST / Sclerostin Antibody (aa38-66, PE) - LS-C269970 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOST / Sclerostin Antibody (aa38-66, Azide-free, HRP) - LS-C269969 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOST / Sclerostin Antibody (aa38-66, FITC) - LS-C269968 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOST / Sclerostin Antibody (aa20-49, Biotin) - LS-C269973 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more