Gene Symbol |
SOST
|
Entrez Gene |
50964
|
Alt Symbol |
CDD, SOST1, VBCH
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
sclerostin
|
Other Description |
-
|
Swissprots |
Q9BQB4 Q495N9
|
Accessions |
AAK13451 CAI46877 CEF39438 EAW51669 Q9BQB4 AF170491 AAQ13601 AF184211 AAQ13694 AF326739 AAK13454 AF331844 AAK16158 AY358203 AAQ88570 AY358627 AAQ88990 BC101086 AAI01087 BC101087 AAI01088 BC101088 AAI01089 BC101089 AAI01090 NM_025237 NP_079513
|
Function |
Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. {ECO:0000269|PubMed:15908424}.
|
Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20551380}.
|
Tissue Specificity |
Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level). {ECO:0000269|PubMed:20551380}.
|
Top Pathways |
Wnt signaling pathway
|