SOST

Gene Symbol	SOST
Entrez Gene	50964
Alt Symbol	CDD, SOST1, VBCH
Species	Human
Gene Type	protein-coding
Description	sclerostin
Other Description	-
Swissprots	Q9BQB4 Q495N9
Accessions	AAK13451 CAI46877 CEF39438 EAW51669 Q9BQB4 AF170491 AAQ13601 AF184211 AAQ13694 AF326739 AAK13454 AF331844 AAK16158 AY358203 AAQ88570 AY358627 AAQ88990 BC101086 AAI01087 BC101087 AAI01088 BC101088 AAI01089 BC101089 AAI01090 NM_025237 NP_079513
Function	Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. {ECO:0000269|PubMed:15908424}.
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20551380}.
Tissue Specificity	Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level). {ECO:0000269|PubMed:20551380}.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Sclerostin full length protein - ab175465 from Abcam Category Protein Source E. coli Species Human

Human Sclerostin full length protein - ab167702 from Abcam Category Protein Source HEK 293 cells Species Human

SOST / Sclerostin Antibody Blocking Peptide - LS-E4993 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SOST / Sclerostin Antibody Blocking Peptide - LS-E8157 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SOST / Sclerostin Antibody Blocking Peptide - LS-E23176 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SOST-Antibody-N-term-Blocking-Peptide - BP17391a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SOST-Antibody-Center-Blocking-Peptide - BP6261c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human SOST/Sclerostin - 1406-ST-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gln24-Tyr213, with an N-terminal 7-His tag

Recombinant Human SOST/Sclerostin, CF - 1406-ST-025/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gln24-Tyr213, with an N-terminal 7-His tag

Human SOST protein - orb191266 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 2 μg, 10 μg Source E. coli Species Human

Human SOST His tag protein - orb83125 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source Human Species Human

Sclerostin Recombinant Protein - 96-397 from ProSci Category Protein Prices $500.00 Sizes 100 µg Source HEK293 cells Species Human

Sclerostin Recombinant Protein (biotin) - 96-703 from ProSci Category Protein Source HEK293 cells Species Human

SOST fusion protein - Ag16567 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SOST fusion protein - Ag15704 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human SOST Protein - BP002652-CD48 from Syd Labs Category Protein Prices $180.00, $528.00, $2,880.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

Recombinant Human SOST, His-tagged - SOST-925H from Creative Biomart Category Protein Source NS0 cells Species Human

Recombinant Human SOST, His tagged - SOST-870H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human SOST, His-tagged, Biotinylated - SOST-270H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human SOST, His-tagged - SOST-2880H from Creative Biomart Category Protein Source E.coli Species Human

Human Sclerostin Recombinant, Biotinylated - RBQ9BQB4 from Reprokine Category Protein Prices $340.00, $590.00, $1,950.00 Sizes 10 µg, 25 µg, 100 µg Source Optimized DNA sequence encoding extracellular domain of Human Sclerostin ( GLN24 - TYR213) including a N-terminal His tag was expressed in HEK293 cells. Recombinant Sclerostin was further labled by Biotin for detection by avidin conjugated secondary probes. Species Human

Human Sclerostin Recombinant - RKQ9BQB4 from Reprokine Category Protein Prices $160.00, $680.00, $2,750.00 Sizes 20 µg, 100 µg, 500 µg Source Optimized DNA sequence encoding extracellular domain of Human Sclerostin ( GLN24 - TYR213) including a N-terminal His tag was expressed in HEK293 cells. Species Human

Recombinant Sclerostin (SOST) - RPC864Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Sclerostin (SOST) - RPC864Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Sclerostin (SOST) - RPC864Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

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