SOST

Gene Symbol SOST
Entrez Gene 50964
Alt Symbol CDD, SOST1, VBCH
Species Human
Gene Type protein-coding
Description sclerostin
Other Description -
Swissprots Q9BQB4 Q495N9
Accessions AAK13451 CAI46877 CEF39438 EAW51669 Q9BQB4 AF170491 AAQ13601 AF184211 AAQ13694 AF326739 AAK13454 AF331844 AAK16158 AY358203 AAQ88570 AY358627 AAQ88990 BC101086 AAI01087 BC101087 AAI01088 BC101088 AAI01089 BC101089 AAI01090 NM_025237 NP_079513
Function Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. {ECO:0000269|PubMed:15908424}.
Subcellular Location Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20551380}.
Tissue Specificity Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level). {ECO:0000269|PubMed:20551380}.
Top Pathways Wnt signaling pathway

Sclerostin CRISPR/Cas9 KO Plasmid (h) - sc-401527 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sclerostin HDR Plasmid (h) - sc-401527-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sclerostin Double Nickase Plasmid (h) - sc-401527-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sclerostin Double Nickase Plasmid (h2) - sc-401527-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sclerostin CRISPR Activation Plasmid (h) - sc-401527-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sclerostin CRISPR Activation Plasmid (h2) - sc-401527-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sclerostin Lentiviral Activation Particles (h) - sc-401527-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sclerostin Lentiviral Activation Particles (h2) - sc-401527-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sclerostin siRNA (h) - sc-61503 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sclerostin shRNA Plasmid (h) - sc-61503-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sclerostin shRNA (h) Lentiviral Particles - sc-61503-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN20344 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20344 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12697 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12697

SOST siRNA (Human) - CRH9440 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SOST - MBS8214073 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Sclerostin CRISPR/Cas9 KO Plasmid (h2) - sc-401527-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sclerostin HDR Plasmid (h2) - sc-401527-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human SOST (NM_025237.2) - SHH415232 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SOST(NM_025237.2) - SHL016878 from Creative biogene

Category siRNA
Species Reactivities Human

Human SOST siRNA - orb269942 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SOST shRNA Plasmid (Human) - CHH9440 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SOST miRNA 3'UTR clone - MiUTR1H-09756 from Creative biogene

Species Reactivities Human
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