MOCS2

Gene Symbol MOCS2
Entrez Gene 4338
Alt Symbol MCBPE, MOCO1, MOCODB, MPTS
Species Human
Gene Type protein-coding
Description molybdenum cofactor synthesis 2
Other Description MOCS2A|MOCS2B|molybdenum cofactor biosynthesis protein E|molybdopterin synthase small and large subunit|molybdopterin synthase sulfur carrier subunit
Swissprots O96007 O96033 Q6IAI3
Accessions CBG03804 CBV17326 EAW54874 EAW54875 EAW54876 EAW54877 O96007 O96033 AA252410 AF091871 AAD14598 AF117815 AAD13296 AF155659 AAF67478 AK095832 AK126211 AK312887 BAG35735 BC029287 BC039720 BC046097 AAH46097 BC095417 CB050849 CD514049 CR457172 CAG33453 DA967651 NM_004531 NP_004522 NM_176806 NP_789776
Function Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. {ECO:0000255|HAMAP-Rule:MF_03052, ECO:0000269|PubMed:12732628, ECO:0000269|PubMed:15073332}.
Subcellular Location Cytoplasm, cytosol {ECO:0000255|HAMAP- Rule:MF_03052, ECO:0000269|PubMed:15073332}.
Tissue Specificity Highest levels are found in heart and skeletal muscle. Lower levels are present in brain, kidney and pancreas. Very low levels are found in lung and peripheral blood leukocytes. {ECO:0000269|PubMed:10053003}.
Top Pathways Sulfur relay system, Folate biosynthesis

MOCS2 (F-9) - sc-377169 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MOCS2 (F-9): sc-377169. Western blot analysis of MOCS2 expression in non-transfected 293T: sc-117752 (A), human MOCS2 transfected 293T: sc-116247 (B) and Jurkat (C) whole cell lysates.

MOCS2 (G-9) - sc-377343 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MOCS2 (G-9): sc-377343. Western blot analysis of MOCS2 expression in non-transfected: sc-117752 (A) and human MOCS2 transfected: sc-116247 (B) 293T whole cell lysates.

MOCS2 (C-13) - sc-54104 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MOCS2 (C-13): sc-54104. Western blot analysis of MOCS2 expression in Jurkat whole cell lysates.

MOCS2 (F-14) - sc-54105 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MOCS2 (F-14): sc-54105. Western blot analysis of MOCS2 expression in non-transfected: sc-117752 (A) and mouse MOCS2 transfected: sc-121709 (B) 293T whole cell lysates.

MOCS2 (FL-188) - sc-134790 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MOCS2 (FL-188): sc-134790. Western blot analysis of MOCS2 expression in non-transfected: sc-117752 (A) and human MOCS2 transfected: sc-116247 (B) 293T whole cell lysates.

MOCS2 (S-17) - sc-54107 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-MOCS2 antibody - ab122406 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab122406, at a 1/25 dilution, staining MOCS2 in cells of tubules of paraffin-embedded Human kidney tissue by immunohistochemistry.

Anti-MOCS2 antibody - ab123968 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MOCS2 antibody (ab123968) at 1/100 dilution + NCI-H460 cell line lysate at 35 µg

Anti-MOCS2 Antibody (clone 4H3) - LS-C197695 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4H3

Anti-MOCS2 Antibody (aa14-43, APC) - LS-C223304 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MOCS2 Antibody (aa14-43, AP) - LS-C223303 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MOCS2 Antibody (aa14-43, PE) - LS-C223308 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MOCS2 Antibody (aa13-43) - LS-C323061 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MOCS2 Antibody (aa14-43, Biotin) - LS-C223305 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MOCS2 Antibody (aa14-43, Azide-free, HRP) - LS-C223307 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MOCS2 Antibody (aa14-43, FITC) - LS-C223306 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MOCS2 Antibody (aa14-43) - LS-C164265 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MOCS2 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The MOCS2 antibody detected the MOCS2 protein (arrow).

MOCS2 Antibody - NBP1-81045 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MOCS2 Antibody [NBP1-81045] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

MOCS2 Antibody - NBP2-38359 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MOCS2 Antibody - NBP2-17319 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MOCS2 Antibody [NBP2-17319] - Sample (30 ug of whole cell lysate) A: Hela 12% SDS PAGE gel, diluted at 1:5000.

MOCS2 Antibody (4H3) - H00004338-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4H3

Anti-MOCS2 antibody produced in rabbit - HPA037680 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MOCS2: <B>Cat. No. HPA037680</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells of tubules.

Monoclonal Anti-MOCS2 antibody produced in mouse - SAB1409320 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4H3
<B>Immunoblotting</B><BR/>Monoclonal Anti-MOCS2: <B>Cat. No. SAB1409320</B>: Antibody concentration: 1 μg/mL. Specific band of ~36.2 kDa using immunogen protein lysate.

Anti-MOCS2 (166-180) antibody produced in rabbit - SAB1100272 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-MOCS2 (166-180), <B>Cat. No. SAB1100272</B>: Immunofluorescence of HUVEC cells using Anti-MOCS2 (166-180), SAB1100272 (red), taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-MOCS2 (31-43) antibody produced in rabbit - SAB1100271 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-MOCS2 (31-43), <B>Cat. No. SAB1100271</B>: Immunofluorescence of HUVEC cells using Anti-MOCS2 (31-43), SAB1100271 (red), taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com
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