Gene Symbol | MOCS2 |
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Entrez Gene | 4338 |
Alt Symbol | MCBPE, MOCO1, MOCODB, MPTS |
Species | Human |
Gene Type | protein-coding |
Description | molybdenum cofactor synthesis 2 |
Other Description | MOCS2A|MOCS2B|molybdenum cofactor biosynthesis protein E|molybdopterin synthase small and large subunit|molybdopterin synthase sulfur carrier subunit |
Swissprots | O96007 O96033 Q6IAI3 |
Accessions | CBG03804 CBV17326 EAW54874 EAW54875 EAW54876 EAW54877 O96007 O96033 AA252410 AF091871 AAD14598 AF117815 AAD13296 AF155659 AAF67478 AK095832 AK126211 AK312887 BAG35735 BC029287 BC039720 BC046097 AAH46097 BC095417 CB050849 CD514049 CR457172 CAG33453 DA967651 NM_004531 NP_004522 NM_176806 NP_789776 |
Function | Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. {ECO:0000255|HAMAP-Rule:MF_03052, ECO:0000269|PubMed:12732628, ECO:0000269|PubMed:15073332}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000255|HAMAP- Rule:MF_03052, ECO:0000269|PubMed:15073332}. |
Tissue Specificity | Highest levels are found in heart and skeletal muscle. Lower levels are present in brain, kidney and pancreas. Very low levels are found in lung and peripheral blood leukocytes. {ECO:0000269|PubMed:10053003}. |
Top Pathways | Sulfur relay system, Folate biosynthesis |
MOCS2 CRISPR/Cas9 KO Plasmid (h) - sc-407720 from Santa Cruz Biotechnology
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MOCS2 HDR Plasmid (h) - sc-407720-HDR from Santa Cruz Biotechnology
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MOCS2 Double Nickase Plasmid (h) - sc-407720-NIC from Santa Cruz Biotechnology
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MOCS2 Double Nickase Plasmid (h2) - sc-407720-NIC-2 from Santa Cruz Biotechnology
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MOCS2 CRISPR Activation Plasmid (h) - sc-407720-ACT from Santa Cruz Biotechnology
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MOCS2 CRISPR Activation Plasmid (h2) - sc-407720-ACT-2 from Santa Cruz Biotechnology
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MOCS2 Lentiviral Activation Particles (h) - sc-407720-LAC from Santa Cruz Biotechnology
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MOCS2 Lentiviral Activation Particles (h2) - sc-407720-LAC-2 from Santa Cruz Biotechnology
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MOCS2 siRNA (h) - sc-72268 from Santa Cruz Biotechnology
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MOCS2 shRNA Plasmid (h) - sc-72268-SH from Santa Cruz Biotechnology
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MOCS2 shRNA (h) Lentiviral Particles - sc-72268-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU079461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14460 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14460 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05921 from Sigma-Aldrich
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MOCS2 siRNA (Human) - CRH2947 from Cohesion Biosciences
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MOCS2 siRNA (Human) - CRH2948 from Cohesion Biosciences
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shRNA set against Human MOCS2 (NM_176806.2) - SHH343380 from Creative biogene
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shRNA set against Human MOCS2(NM_004531.3) - SHH195149 from Creative biogene
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shRNA set against Human MOCS2(NM_176806.2) - SHH195203 from Creative biogene
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Human MOCS2 siRNA - orb263450 from Biorbyt
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Human MOCS2 siRNA - orb263449 from Biorbyt
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MOCS2 shRNA Plasmid (Human) - CHH2947 from Cohesion Biosciences
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MOCS2 shRNA Plasmid (Human) - CHH2948 from Cohesion Biosciences
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MOCS2 miRNA 3'UTR clone - MiUTR1H-06375 from Creative biogene
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