| Gene Symbol |
MOCS2
|
| Entrez Gene |
4338
|
| Alt Symbol |
MCBPE, MOCO1, MOCODB, MPTS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
molybdenum cofactor synthesis 2
|
| Other Description |
MOCS2A|MOCS2B|molybdenum cofactor biosynthesis protein E|molybdopterin synthase small and large subunit|molybdopterin synthase sulfur carrier subunit
|
| Swissprots |
O96007 O96033 Q6IAI3
|
| Accessions |
CBG03804 CBV17326 EAW54874 EAW54875 EAW54876 EAW54877 O96007 O96033 AA252410 AF091871 AAD14598 AF117815 AAD13296 AF155659 AAF67478 AK095832 AK126211 AK312887 BAG35735 BC029287 BC039720 BC046097 AAH46097 BC095417 CB050849 CD514049 CR457172 CAG33453 DA967651 NM_004531 NP_004522 NM_176806 NP_789776
|
| Function |
Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. {ECO:0000255|HAMAP-Rule:MF_03052, ECO:0000269|PubMed:12732628, ECO:0000269|PubMed:15073332}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000255|HAMAP- Rule:MF_03052, ECO:0000269|PubMed:15073332}.
|
| Tissue Specificity |
Highest levels are found in heart and skeletal muscle. Lower levels are present in brain, kidney and pancreas. Very low levels are found in lung and peripheral blood leukocytes. {ECO:0000269|PubMed:10053003}.
|
| Top Pathways |
Sulfur relay system, Folate biosynthesis
|