Shh

Gene Symbol Shh
Entrez Gene 20423
Alt Symbol 9530036O11Rik, Dsh, Hhg1, Hx, Hxl3, M100081
Species Mouse
Gene Type protein-coding
Description sonic hedgehog
Other Description HHG-1|hemimelic extra toes|short digits|sonic hedgehog protein
Swissprots Q62226
Accessions EDL37231 Q62226 AK077688 BAC36956 BC063087 AAH63087 EU664592 ACD69663 X76290 CAA53922 XM_006535648 XP_006535711 XM_006535649 XP_006535712 NM_009170 NP_033196
Function Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO. {ECO:0000269|PubMed:14687547, ECO:0000269|PubMed:7736596}.
Subcellular Location Sonic hedgehog protein C-product: Secreted, extracellular space. Note=The C-terminal peptide diffuses from the cell.
Tissue Specificity Expressed in a number of embryonic tissues including the notochord, ventral neural tube, floor plate, lung bud, zone of polarizing activity and posterior distal mesenchyme of limbs. In the adult, expressed in lung and neural retina.
Top Pathways Hedgehog signaling pathway, Basal cell carcinoma

Anti-Sonic Hedgehog antibody [RM0128-4A37] - ab86462 from Abcam

Prices $378.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone RM0128-4A37
ab86462 staining Sonic Hedgehog on an E11.5 mouse embryo by immunohistochemistry (left). The tissue was paraformaldehyde fixed and blocked in 1% BSA for 30 mins at RT. The primary antibody was diluted 1/100 and incubated with the sample for 16 hours at 4°C. An Alexa Fluor 488 conjugated donkey anti-rat antibody was used as the secondary. DAPI was used to stain the nuclei (right).See Abreview

Anti-Sonic Hedgehog antibody - C-terminal - ab202342 from Abcam

Prices $359.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Sonic Hedgehog antibody - C-terminal (ab202342) at 1/1000 dilutionLane 1 : Mouse liver lysateLane 2 : Mouse stomach lysateLane 3 : Rat lung tissue lysateLysates/proteins at 20 µg per lane.SecondaryGoat anti-rabbit IgG H&L(HRP) at 1/10000 dilution

Sonic Hedgehog/Shh Antibody - C-Terminus - AF445 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of human stomach tissue and mouse stomach tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Mouse Sonic Hedgehog/Shh C-Terminus Antigen Affinity-purified Polyclonal Antibody (Catalog # AF445) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for Sonic Hedgehog/Shh at approximately 50 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Sonic Hedgehog/Shh Antibody [Biotin] - BAF445 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of human stomach tissue and mouse stomach tissue. PVDF membrane was probed with 2 µg/mL of Goat Anti-Mouse Sonic Hedgehog/Shh C-Terminus Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF445) followed by Streptavidin-HRP. A specific band was detected for Sonic Hedgehog/Shh at approximately 50 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Sonic Hedgehog/Shh Antibody (171028) [Biotin] - BAM4642 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone 171028

Anti-Sonic Hedgehog peptide (N-terminal) antibody produced in goat - S9572 from Sigma-Aldrich

Prices $451.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Monoclonal Anti-Sonic Hedgehog Peptide (C-terminal) antibody produced in rat - S9947 from Sigma-Aldrich

Prices $375.50
Sizes 500 µg
Host Rat
Clonality Monoclonal
Clone 55626

Anti-Sonic Hedgehog peptide (C-terminal) antibody produced in goat - S9822 from Sigma-Aldrich

Prices $451.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Mouse-Shh-Antibody-C-term - AP20881c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded M. lung section using (Mouse) Shh Antibody (C-term)(Cat#AP20881c). AP20881c was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.

Mouse-Shh-Antibody-C-term - AP21097a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Flow cytometric analysis of Hela cells using (Mouse) Shh Antibody (C-term)(green, Cat#AP21097a) compared to an isotype control of rabbit IgG(blue). AP21097a was diluted at 1:25 dilution. An Alexa Fluor® 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.

Mouse-Shh-Antibody-C-term - AW5359 from Abgent, a WuXi AppTec company

Prices $110.00, $325.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Shh Antibody (C-term)(AW5359) at 1/1000 dilution Lane 1: mouse liver lysates Lane 2: mouse lung lysates Lane 3: mouse stomach lysates Lane 4: rat lung lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 57 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

Mouse-Shh-Antibody-N-term - AP21229a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Shh Antibody (N-term) at 1:2000 dilution Lane 1: F9 whole cell lysate Lane 2: mouse stomach lysates Lane 3: rat liver whole cell lysates Lane 4: NIH/3T3 lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 48 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 84 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

Sonic Hedgehog Homolog (Drosophila) Antibody - abx115728 from Abbexa

Host Rabbit
Clonality Polyclonal

Sonic hedgehog (SHH) (N-term) antibody - AM33478PU-N from Acris Antibodies

Prices $480.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 6K12

Sonic hedgehog (SHH) (C-term) antibody - DM3594P from Acris Antibodies

Prices $480.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 4A37

Anti-Hedgehog Homolog, Sonic (SHH) - 20-4159 from ARP American Research Products

Prices $319.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Sonic Hedgehog, Monoclonal Antibody - MBS690703 from MyBioSource

Prices $460.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone (6K12)

Sonic Hedgehog, Monoclonal Antibody - MBS605535 from MyBioSource

Prices $590.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone 9H273

Sonic Hedgehog (Shh) C-terminal, Monoclonal Antibody - MBS690506 from MyBioSource

Prices $460.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone (4A37)

Sonic Hedgehog - GT15032 from Neuromics

Prices $365.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Image: Detection of Sonic Hedge Hog (Shh N-terminal peptide) in cryostat tissue sections of rat cerebellum (dilution10 µg/mL). Tissues were using anti-goat HRP-DAB Cell (brown) and counterstained with hematoxylin (blue).

Anti-SHH monoclonal antibody, clone 282129 - DCABH-8992 from Creative Diagnostics

Host Rat
Clonality Monoclonal
Clone 282129

Rat anti-Mouse Sonic Hedgehog/Shh Monoclonal antibody [clone 282029] - DCABY-3927 from Creative Diagnostics

Host Rat
Clonality Monoclonal
Clone 282029

Rat anti-Mouse Sonic Hedgehog/Shh Monoclonal antibody [clone 282039], Biotin-Conjugated - DCABY-4318 from Creative Diagnostics

Host Rat
Clonality Monoclonal
Clone 282039

SHH Antibody - CSB-PA021266GA01HU from Cusabio

Host Rabbit

Polyclonal Antibody to Hedgehog Homolog, Sonic (SHH) - PAB831Mu01 from Cloud-clone

Host Rabbit
Clonality Polyclonal
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