Shh

Gene Symbol	Shh
Entrez Gene	20423
Alt Symbol	9530036O11Rik, Dsh, Hhg1, Hx, Hxl3, M100081
Species	Mouse
Gene Type	protein-coding
Description	sonic hedgehog
Other Description	HHG-1|hemimelic extra toes|short digits|sonic hedgehog protein
Swissprots	Q62226
Accessions	EDL37231 Q62226 AK077688 BAC36956 BC063087 AAH63087 EU664592 ACD69663 X76290 CAA53922 XM_006535648 XP_006535711 XM_006535649 XP_006535712 NM_009170 NP_033196
Function	Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO. {ECO:0000269|PubMed:14687547, ECO:0000269|PubMed:7736596}.
Subcellular Location	Sonic hedgehog protein C-product: Secreted, extracellular space. Note=The C-terminal peptide diffuses from the cell.
Tissue Specificity	Expressed in a number of embryonic tissues including the notochord, ventral neural tube, floor plate, lung bud, zone of polarizing activity and posterior distal mesenchyme of limbs. In the adult, expressed in lung and neural retina.
Top Pathways	Hedgehog signaling pathway, Basal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant Mouse Sonic Hedgehog/Shh Protein - NBP2-35174 from Novus Biologicals Category Protein Prices $69.00, $149.00, $2,499.00 Sizes 5 µg, 25 µg, 1 mg Source E. coli

Mouse Sonic Hedgehog/Shh Biologically Active Protein - NBP2-35339 from Novus Biologicals Category Protein Prices $69.00, $169.00 Sizes 5 µg, 25 µg Source E. coli

Sonic Hedgehog/Shh Recombinant Protein - P4621 from Novus Biologicals Category Protein Prices $549.00 Sizes 25 µg Species Mouse

Sonic Hedgehog/Shh Protein - NBP1-99300 from Novus Biologicals Category Protein Species Mouse

Recombinant Mouse Sonic Hedgehog/Shh Protein - NBP1-99689 from Novus Biologicals Category Protein Prices $595.00 Sizes 100 µg Source E. coli

Sonic Hedgehog/Shh Recombinant Protein - P4339 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Species Mouse

Recombinant Mouse Sonic Hedgehog/Shh (C25II) N-Terminus - 464-SH-025 from R&D Systems Category Protein Source E. coli-derived, Cys25-Gly198 (Cys25Ile-Ile), with an N-terminal Met

Recombinant Mouse Sonic Hedgehog/Shh (C25II) N-Terminus - 464-SH-200 from R&D Systems Category Protein Source E. coli-derived, Cys25-Gly198 (Cys25Ile-Ile), with an N-terminal Met

Recombinant Mouse Sonic Hedgehog/Shh (C25II) N-Terminus, CF - 464-SH-025/CF from R&D Systems Category Protein Source E. coli-derived, Cys25-Gly198 (Cys25Ile-Ile), with an N-terminal Met

Recombinant Mouse Sonic Hedgehog/Shh (C25II) N-Terminus, CF - 464-SH-200/CF from R&D Systems Category Protein Source E. coli-derived, Cys25-Gly198 (Cys25Ile-Ile), with an N-terminal Met

Recombinant Mouse Sonic Hedgehog/Shh, N-Terminus - 461-SH-025 from R&D Systems Category Protein Source E. coli-derived, Cys25-Gly198, with a C-terminal 6-His tag

Recombinant Mouse Sonic Hedgehog/Shh, N-Terminus, CF - 461-SH-025/CF from R&D Systems Category Protein Source E. coli-derived, Cys25-Gly198, with a C-terminal 6-His tag

SHH Protein (OPPA01657) - OPPA01657 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

SHH Protein (OPPA02401) - OPPA02401 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Mouse HHG1 protein - orb139682 from Biorbyt Category Protein Prices $162.00, $298.00, $731.00 Sizes 5 μg, 20 μg, 100 μg Source Human Cells Species Mouse

Sonic Hedgehog protein - 30R-2432 from Fitzgerald Category Protein Prices $235.00 Sizes 25 µg Source E.coli Species Mouse

Mouse SHH Protein - abx067032 from Abbexa Category Protein Source E.coli Species Mouse

Sonic hedgehog (SHH) (25-198, His-tag) - AR09447PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Mouse

Sonic hedgehog (SHH) (25-198, His-tag) - AR09447PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Mouse

Sonic hedgehog (SHH) - AR31089PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 25 µg Source E. coli Species Mouse

Sonic hedgehog (SHH) - AR31089PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 5 µg Source E. coli Species Mouse

Sonic hedgehog (SHH) - P4339 from Acris Antibodies Category Protein Prices $430.00 Sizes 100 µg Species Mouse

Sonic Hedgehog (Shh), Recombinant Mouse - 213-10408-1 from RayBiotech Category Protein Prices $75.00 Sizes 1 µg Source Escherichia coli (E.coli) Species Mouse

Recombinant Murine Sonic Hedgehog (Shh) - 213-10408-2 from RayBiotech Category Protein Prices $190.00 Sizes 2 µg Source Escherichia coli (E.coli) Species Mouse

Sonic Hedgehog, Mouse Recombinant - 228-11429-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Mouse

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