Shh

Gene Symbol Shh
Entrez Gene 20423
Alt Symbol 9530036O11Rik, Dsh, Hhg1, Hx, Hxl3, M100081
Species Mouse
Gene Type protein-coding
Description sonic hedgehog
Other Description HHG-1|hemimelic extra toes|short digits|sonic hedgehog protein
Swissprots Q62226
Accessions EDL37231 Q62226 AK077688 BAC36956 BC063087 AAH63087 EU664592 ACD69663 X76290 CAA53922 XM_006535648 XP_006535711 XM_006535649 XP_006535712 NM_009170 NP_033196
Function Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO. {ECO:0000269|PubMed:14687547, ECO:0000269|PubMed:7736596}.
Subcellular Location Sonic hedgehog protein C-product: Secreted, extracellular space. Note=The C-terminal peptide diffuses from the cell.
Tissue Specificity Expressed in a number of embryonic tissues including the notochord, ventral neural tube, floor plate, lung bud, zone of polarizing activity and posterior distal mesenchyme of limbs. In the adult, expressed in lung and neural retina.
Top Pathways Hedgehog signaling pathway, Basal cell carcinoma

Shh CRISPR/Cas9 KO Plasmid (m) - sc-422926 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Shh HDR Plasmid (m) - sc-422926-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Shh Double Nickase Plasmid (m) - sc-422926-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Shh Double Nickase Plasmid (m2) - sc-422926-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Shh CRISPR Activation Plasmid (m) - sc-422926-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Shh CRISPR Activation Plasmid (m2) - sc-422926-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Shh Lentiviral Activation Particles (m) - sc-422926-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Shh Lentiviral Activation Particles (m2) - sc-422926-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Shh siRNA (m) - sc-37205 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Shh shRNA Plasmid (m) - sc-37205-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Shh shRNA (m) Lentiviral Particles - sc-37205-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CompoZr® Knockout ZFN Kit - CKOZFN41144 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND41144 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SHH siRNA (Mouse) - CRM3708 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

SHH - MBS8239775 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse SHH (NM_009170.3) - SHH407060 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Shh(NM_009170.3) - SHR224300 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse SHH siRNA - orb283184 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

SHH shRNA Plasmid (Mouse) - CHM3708 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

SHH miRNA 3'UTR clone - MiUTR1M-10686 from Creative biogene

Species Reactivities Mouse
Search more