Gene Symbol | Shh |
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Entrez Gene | 20423 |
Alt Symbol | 9530036O11Rik, Dsh, Hhg1, Hx, Hxl3, M100081 |
Species | Mouse |
Gene Type | protein-coding |
Description | sonic hedgehog |
Other Description | HHG-1|hemimelic extra toes|short digits|sonic hedgehog protein |
Swissprots | Q62226 |
Accessions | EDL37231 Q62226 AK077688 BAC36956 BC063087 AAH63087 EU664592 ACD69663 X76290 CAA53922 XM_006535648 XP_006535711 XM_006535649 XP_006535712 NM_009170 NP_033196 |
Function | Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO. {ECO:0000269|PubMed:14687547, ECO:0000269|PubMed:7736596}. |
Subcellular Location | Sonic hedgehog protein C-product: Secreted, extracellular space. Note=The C-terminal peptide diffuses from the cell. |
Tissue Specificity | Expressed in a number of embryonic tissues including the notochord, ventral neural tube, floor plate, lung bud, zone of polarizing activity and posterior distal mesenchyme of limbs. In the adult, expressed in lung and neural retina. |
Top Pathways | Hedgehog signaling pathway, Basal cell carcinoma |
Shh CRISPR/Cas9 KO Plasmid (m) - sc-422926 from Santa Cruz Biotechnology
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Shh HDR Plasmid (m) - sc-422926-HDR from Santa Cruz Biotechnology
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Shh Double Nickase Plasmid (m) - sc-422926-NIC from Santa Cruz Biotechnology
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Shh Double Nickase Plasmid (m2) - sc-422926-NIC-2 from Santa Cruz Biotechnology
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Shh CRISPR Activation Plasmid (m) - sc-422926-ACT from Santa Cruz Biotechnology
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Shh CRISPR Activation Plasmid (m2) - sc-422926-ACT-2 from Santa Cruz Biotechnology
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Shh Lentiviral Activation Particles (m) - sc-422926-LAC from Santa Cruz Biotechnology
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Shh Lentiviral Activation Particles (m2) - sc-422926-LAC-2 from Santa Cruz Biotechnology
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Shh siRNA (m) - sc-37205 from Santa Cruz Biotechnology
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Shh shRNA Plasmid (m) - sc-37205-SH from Santa Cruz Biotechnology
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Shh shRNA (m) Lentiviral Particles - sc-37205-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN41144 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND41144 from Sigma-Aldrich
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SHH siRNA (Mouse) - CRM3708 from Cohesion Biosciences
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SHH - MBS8239775 from MyBioSource
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shRNA set against Mouse SHH (NM_009170.3) - SHH407060 from Creative biogene
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shRNA set against Mouse Shh(NM_009170.3) - SHR224300 from Creative biogene
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Mouse SHH siRNA - orb283184 from Biorbyt
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SHH shRNA Plasmid (Mouse) - CHM3708 from Cohesion Biosciences
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SHH miRNA 3'UTR clone - MiUTR1M-10686 from Creative biogene
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