CLSTN1

Gene Symbol	CLSTN1
Entrez Gene	22883
Alt Symbol	ALC-ALPHA, CDHR12, CST-1, CSTN1, PIK3CD, XB31alpha, alcalpha1, alcalpha2
Species	Human
Gene Type	protein-coding
Description	calsyntenin 1
Other Description	alcadein-alpha|alzheimer-related cadherin-like protein|cadherin-related family member 12|calsyntenin-1|non-classical cadherin XB31alpha
Swissprots	Q71MN0 Q5UE58 Q8N4K9 Q5SR52 A8K183 O94985
Accessions	EAW71629 EAW71630 O94985 AB020718 BAA74934 AF438482 AAQ04552 AK000605 AK001591 BAG50945 AK056820 BAG51814 AK225500 AK289798 BAF82487 AK304813 BAG65563 AY545556 AY753301 AAV30551 BC033902 AAH33902 BI335759 CB132727 DQ891263 ABM82189 DQ894450 ABM85376 NM_001009566 NP_001009566 NM_001302883 NP_001289812 NM_014944 NP_055759
Function	Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals (By similarity). {ECO:0000250}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:17332754}; Single-pass type I membrane protein {ECO:0000269|PubMed:17332754}. Golgi apparatus membrane {ECO:0000269|PubMed:17332754}. Cell projection {ECO:0000269|PubMed:17332754}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000269|PubMed:17332754}. Note=Neurite tips. Localized in the postsynaptic membrane of both excitatory and inhibitory synapses (By similarity). The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. {ECO:0000250}.
Tissue Specificity	Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level). {ECO:0000269|PubMed:12498782, ECO:0000269|PubMed:12972431}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

calsyntenin-1 (A-4) - sc-393383 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

calsyntenin-1 (H-132) - sc-368132 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

calsyntenin-1 (T-17) - sc-133315 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

calsyntenin-1 (N-12) - sc-133314 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-CLSTN1 antibody - ab73141 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CLSTN1 antibody - ab99179 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CLSTN1 antibody [EPR2963] - ab134130 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR2963

Anti-CLSTN1 antibody - N-terminal - ab139116 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-CS1 / CLSTN1 Antibody (aa35-84) IHC-plus™ - LS-B9743 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CS1 / CLSTN1 Antibody (C-Terminus, clone EPR2963) IHC-plus™ - LS-B11113 from LifeSpan Bioscience Host Rabbit Clonality Monoclonal Clone [EPR2963]

Anti-CS1 / CLSTN1 Antibody (C-Terminus) - LS-C144685 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CS1 / CLSTN1 Antibody (C-Terminus) - LS-C153284 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CS1 / CLSTN1 Antibody (aa15-42, AP) - LS-C233985 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CS1 / CLSTN1 Antibody (aa15-42, APC) - LS-C233986 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CS1 / CLSTN1 Antibody (aa15-42, Biotin) - LS-C233987 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CS1 / CLSTN1 Antibody (aa15-42, FITC) - LS-C233988 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CS1 / CLSTN1 Antibody (aa15-42, PE) - LS-C233990 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CS1 / CLSTN1 Antibody (aa15-42, Azide-free, HRP) - LS-C249705 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CS1 / CLSTN1 Antibody (aa15-42) - LS-C159372 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CS1 / CLSTN1 Antibody (aa15-42) - LS-C320461 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CS1 / CLSTN1 Antibody - LS-C309937 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Calsyntenin-1 Antibody - AF5346 from Novus Biologicals Prices $99.00, $365.00 Sizes 25 µg, 100 µg Host Sheep Clonality Polyclonal

Calsyntenin-1 Antibody - NBP1-85706 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Calsyntenin-1 Antibody - NBP1-59862 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

PI 3-Kinase p110 delta Antibody - NBP2-38535 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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