CLSTN1

Gene Symbol	CLSTN1
Entrez Gene	22883
Alt Symbol	ALC-ALPHA, CDHR12, CST-1, CSTN1, PIK3CD, XB31alpha, alcalpha1, alcalpha2
Species	Human
Gene Type	protein-coding
Description	calsyntenin 1
Other Description	alcadein-alpha|alzheimer-related cadherin-like protein|cadherin-related family member 12|calsyntenin-1|non-classical cadherin XB31alpha
Swissprots	Q71MN0 Q5UE58 Q8N4K9 Q5SR52 A8K183 O94985
Accessions	EAW71629 EAW71630 O94985 AB020718 BAA74934 AF438482 AAQ04552 AK000605 AK001591 BAG50945 AK056820 BAG51814 AK225500 AK289798 BAF82487 AK304813 BAG65563 AY545556 AY753301 AAV30551 BC033902 AAH33902 BI335759 CB132727 DQ891263 ABM82189 DQ894450 ABM85376 NM_001009566 NP_001009566 NM_001302883 NP_001289812 NM_014944 NP_055759
Function	Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals (By similarity). {ECO:0000250}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:17332754}; Single-pass type I membrane protein {ECO:0000269|PubMed:17332754}. Golgi apparatus membrane {ECO:0000269|PubMed:17332754}. Cell projection {ECO:0000269|PubMed:17332754}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000269|PubMed:17332754}. Note=Neurite tips. Localized in the postsynaptic membrane of both excitatory and inhibitory synapses (By similarity). The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. {ECO:0000250}.
Tissue Specificity	Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level). {ECO:0000269|PubMed:12498782, ECO:0000269|PubMed:12972431}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CLSTN1 full length protein - ab161459 from Abcam Category Protein Source Wheat germ Species Human

Human CLSTN1 protein fragment - ab161460 from Abcam Category Protein Source Wheat germ Species Human

Human CLSTN1 protein fragment - ab161461 from Abcam Category Protein Source Wheat germ Species Human

Human CLSTN1 protein fragment - ab182805 from Abcam Category Protein Source E. coli Species Human

PIK3CD / PI3K Delta Antibody Blocking Peptide - LS-E7389 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIK3CD / PI3K Delta Antibody Blocking Peptide - LS-E9430 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Calsyntenin-1 Protein - H00022883-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Calsyntenin-1 Partial Recombinant Protein - H00022883-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PI 3-Kinase p110 delta Protein - H00005293-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Calsyntenin-1 Protein - H00022883-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PI 3-Kinase p110 delta Peptide - P1626 from Novus Biologicals Category Peptide Species Human

PI 3-Kinase p110 delta Peptide - P1597 from Novus Biologicals Category Peptide Species Human

PI 3-Kinase p110 delta Peptide - P2994 from Novus Biologicals Category Peptide Species Human

CLSTN1-Antibody-N-term-Blocking-Peptide - BP18952a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Calsyntenin-1, CF - 5346-CL-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Arg30-Thr851, with a C-terminal 6-His tag

Human Calsyntenin-1 (His Tag) protein - orb232416 from Biorbyt Category Protein Prices $400.00, $816.00 Sizes 50 μg, 200 μg Species Human

Calsyntenin 1 Blocking Peptide - 33R-4599 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Calsyntenin-1 - H00022883-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Calsyntenin-1 - H00022883-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Calsyntenin-1 - H00022883-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Calsyntenin-1 - H00022883-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Calsyntenin-1 - H00022883-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Calsyntenin-1 - H00022883-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Calsyntenin-1 - H00022883-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CLSTN1 fusion protein - ag3504 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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