| Gene Symbol |
CLSTN1
|
| Entrez Gene |
22883
|
| Alt Symbol |
ALC-ALPHA, CDHR12, CST-1, CSTN1, PIK3CD, XB31alpha, alcalpha1, alcalpha2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calsyntenin 1
|
| Other Description |
alcadein-alpha|alzheimer-related cadherin-like protein|cadherin-related family member 12|calsyntenin-1|non-classical cadherin XB31alpha
|
| Swissprots |
Q71MN0 Q5UE58 Q8N4K9 Q5SR52 A8K183 O94985
|
| Accessions |
EAW71629 EAW71630 O94985 AB020718 BAA74934 AF438482 AAQ04552 AK000605 AK001591 BAG50945 AK056820 BAG51814 AK225500 AK289798 BAF82487 AK304813 BAG65563 AY545556 AY753301 AAV30551 BC033902 AAH33902 BI335759 CB132727 DQ891263 ABM82189 DQ894450 ABM85376 NM_001009566 NP_001009566 NM_001302883 NP_001289812 NM_014944 NP_055759
|
| Function |
Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:17332754}; Single-pass type I membrane protein {ECO:0000269|PubMed:17332754}. Golgi apparatus membrane {ECO:0000269|PubMed:17332754}. Cell projection {ECO:0000269|PubMed:17332754}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000269|PubMed:17332754}. Note=Neurite tips. Localized in the postsynaptic membrane of both excitatory and inhibitory synapses (By similarity). The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level). {ECO:0000269|PubMed:12498782, ECO:0000269|PubMed:12972431}.
|