CLSTN1
| Gene Symbol | CLSTN1 |
|---|---|
| Entrez Gene | 22883 |
| Alt Symbol | ALC-ALPHA, CDHR12, CST-1, CSTN1, PIK3CD, XB31alpha, alcalpha1, alcalpha2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | calsyntenin 1 |
| Other Description | alcadein-alpha|alzheimer-related cadherin-like protein|cadherin-related family member 12|calsyntenin-1|non-classical cadherin XB31alpha |
| Swissprots | Q71MN0 Q5UE58 Q8N4K9 Q5SR52 A8K183 O94985 |
| Accessions | EAW71629 EAW71630 O94985 AB020718 BAA74934 AF438482 AAQ04552 AK000605 AK001591 BAG50945 AK056820 BAG51814 AK225500 AK289798 BAF82487 AK304813 BAG65563 AY545556 AY753301 AAV30551 BC033902 AAH33902 BI335759 CB132727 DQ891263 ABM82189 DQ894450 ABM85376 NM_001009566 NP_001009566 NM_001302883 NP_001289812 NM_014944 NP_055759 |
| Function | Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals (By similarity). {ECO:0000250}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:17332754}; Single-pass type I membrane protein {ECO:0000269|PubMed:17332754}. Golgi apparatus membrane {ECO:0000269|PubMed:17332754}. Cell projection {ECO:0000269|PubMed:17332754}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000269|PubMed:17332754}. Note=Neurite tips. Localized in the postsynaptic membrane of both excitatory and inhibitory synapses (By similarity). The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. {ECO:0000250}. |
| Tissue Specificity | Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level). {ECO:0000269|PubMed:12498782, ECO:0000269|PubMed:12972431}. |
calsyntenin-1 CRISPR/Cas9 KO Plasmid (h) - sc-408199 from Santa Cruz Biotechnology
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calsyntenin-1 HDR Plasmid (h) - sc-408199-HDR from Santa Cruz Biotechnology
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calsyntenin-1 Double Nickase Plasmid (h) - sc-408199-NIC from Santa Cruz Biotechnology
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calsyntenin-1 Double Nickase Plasmid (h2) - sc-408199-NIC-2 from Santa Cruz Biotechnology
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calsyntenin-1 CRISPR Activation Plasmid (h) - sc-408199-ACT from Santa Cruz Biotechnology
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calsyntenin-1 CRISPR Activation Plasmid (h2) - sc-408199-ACT-2 from Santa Cruz Biotechnology
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calsyntenin-1 Lentiviral Activation Particles (h) - sc-408199-LAC from Santa Cruz Biotechnology
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calsyntenin-1 Lentiviral Activation Particles (h2) - sc-408199-LAC-2 from Santa Cruz Biotechnology
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calsyntenin-1 siRNA (h) - sc-88549 from Santa Cruz Biotechnology
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calsyntenin-1 shRNA Plasmid (h) - sc-88549-SH from Santa Cruz Biotechnology
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calsyntenin-1 shRNA (h) Lentiviral Particles - sc-88549-V from Santa Cruz Biotechnology
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PI 3-Kinase p110 delta RNAi - H00005293-R02 from Novus Biologicals
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Calsyntenin-1 RNAi - H00022883-R01 from Novus Biologicals
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MISSION® esiRNA - EHU085691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6266 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6266 from Sigma-Aldrich
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CLSTN1 siRNA (Human) - CRH7840 from Cohesion Biosciences
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Calsyntenin-1 RNAi - H00022883-R02 from Novus Biologicals
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CLSTN1 - MBS8202020 from MyBioSource
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shRNA set against Human CLSTN1 (NM_014944.3) - SHH265697 from Creative biogene
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shRNA set against Human CLSTN1(NM_014944.3) - SHG184297 from Creative biogene
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shRNA set against Human CLSTN1(NM_001009566.1) - SHG184299 from Creative biogene
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shRNA set against Human CLSTN1(NM_014944.3) - SHG184425 from Creative biogene
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shRNA set against Human CLSTN1(NM_001009566.1) - SHG184441 from Creative biogene
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Human CLSTN1 siRNA - orb268342 from Biorbyt
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