SYVN1

Gene Symbol SYVN1
Entrez Gene 84447
Alt Symbol DER3, HRD1
Species Human
Gene Type protein-coding
Description synovial apoptosis inhibitor 1, synoviolin
Other Description E3 ubiquitin-protein ligase synoviolin|HMG-coA reductase degradation 1 homolog
Swissprots Q86TM6 Q96PK3 Q8N6E8 Q96JL5 Q8N3K3
Accessions EAW74357 EAW74358 EAW74359 EAW74360 EAW74361 EAW74362 Q86TM6 AA864844 AB058713 BAB47439 AB085847 BAC24801 AF317634 AAL26903 AK074148 BAB84974 AK126912 BAG54394 AL834262 CAD38937 BC013860 BC030530 AAH30530 BC035473 BC141662 AAI41663 DQ574657 EU176276 ABW03727 EU176586 ABW03387 EU446616 ABZ92145 XM_011545303 XP_011543605 NM_032431 NP_115807 NM_172230 NP_757385
Function Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16289116, ECO:0000269|Pub
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16186510}; Multi- pass membrane protein {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16186510}.
Tissue Specificity Ubiquitously expressed, with highest levels in liver and kidney (at protein level). Up-regulated in synovial tissues from patients with rheumatoid arthritis (at protein level). {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321}.
Top Pathways Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

SYVN1 (D3O2A) Rabbit mAb - 14773 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3O2A
Western blot analysis of extracts from various cell lines using SYVN1 (D3O2A) Rabbit mAb.

SYVN1 Antibody - 12925 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using SYVN1 Antibody.

Synoviolin (K-17) - sc-79122 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Synoviolin (A-21) - sc-130889 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Synoviolin (A-21): sc-130889. Western blot analysis of Synoviolin expression in non-transfected: sc-117752 (A) and mouse Synoviolin transfected: sc-123873 (B) 293T whole cell lysates.

Anti-SYVN1 antibody - ab118483 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab118483 at 10&microg/ml staining SYVN1 in Formalin-fixed, Paraffin-embedded Human kidney tissue by Immunohistochemistry, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-SYVN1 antibody - ab71482 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SYVN1 antibody (ab71482) at 1/60 dilution + Ramos cell line lysates at 35 µg

Anti-SYVN1 antibody - ab75709 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SYVN1 antibody (ab75709) at 1/50 dilution + Hela cell line lysate at 35 µg

Anti-SYVN1 antibody - ab104495 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SYVN1 antibody [EP7459] - ab170901 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP7459
Immunofluorescence analysis of HeLa cells labeling SYVN1, using ab170901 at a 1/100 dilution (red), and DAPI nuclear staining (blue).

Anti-SYVN1 antibody - Carboxyterminal end - ab38456 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SYVN1 antibody - Carboxyterminal end (ab38456) at 1/100 dilution + mouse kidney tissue lysate

Anti-SYVN1 / HRD1 Antibody (C-Terminus) IHC-plus™ - LS-B3451 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SYVN1 / HRD1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3451 concentration 10 ug/ml.

Anti-SYVN1 / HRD1 Antibody (Internal) - LS-C68245 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SYVN1 / HRD1 Antibody (aa588-617, AP) - LS-C241484 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SYVN1 / HRD1 Antibody (aa588-617, Biotin) - LS-C241485 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SYVN1 / HRD1 Antibody (aa588-617, APC) - LS-C241486 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SYVN1 / HRD1 Antibody (aa588-617, FITC) - LS-C241487 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SYVN1 / HRD1 Antibody (aa588-617, PE) - LS-C241490 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SYVN1 / HRD1 Antibody (aa588-617, Azide-free, HRP) - LS-C248297 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SYVN1 / HRD1 Antibody (aa550-600) - LS-C289653 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SYVN1 / HRD1 Antibody (aa371-420) - LS-C80567 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 1.25 ug/ml. Gel concentration: 12%.

Anti-SYVN1 / HRD1 Antibody (aa567-617) - LS-C289656 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SYVN1 / HRD1 Antibody (aa501-550) - LS-C80568 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 0.25 ug/ml. Gel concentration: 12%.

Anti-SYVN1 / HRD1 Antibody (aa588-617) - LS-C325538 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SYVN1 / HRD1 Antibody (aa115-145) - LS-C165013 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of HRD1 Antibody in SK-BR-3 cell line lysates (35 ug/lane). HRD1 (arrow) was detected using the purified antibody.

Anti-SYVN1 / HRD1 Antibody (aa300-400) - LS-C49024 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of HRD1 in an endogenous 293T cell lysate.
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