SYVN1

Gene Symbol SYVN1
Entrez Gene 84447
Alt Symbol DER3, HRD1
Species Human
Gene Type protein-coding
Description synovial apoptosis inhibitor 1, synoviolin
Other Description E3 ubiquitin-protein ligase synoviolin|HMG-coA reductase degradation 1 homolog
Swissprots Q86TM6 Q96PK3 Q8N6E8 Q96JL5 Q8N3K3
Accessions EAW74357 EAW74358 EAW74359 EAW74360 EAW74361 EAW74362 Q86TM6 AA864844 AB058713 BAB47439 AB085847 BAC24801 AF317634 AAL26903 AK074148 BAB84974 AK126912 BAG54394 AL834262 CAD38937 BC013860 BC030530 AAH30530 BC035473 BC141662 AAI41663 DQ574657 EU176276 ABW03727 EU176586 ABW03387 EU446616 ABZ92145 XM_011545303 XP_011543605 NM_032431 NP_115807 NM_172230 NP_757385
Function Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16289116, ECO:0000269|Pub
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16186510}; Multi- pass membrane protein {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16186510}.
Tissue Specificity Ubiquitously expressed, with highest levels in liver and kidney (at protein level). Up-regulated in synovial tissues from patients with rheumatoid arthritis (at protein level). {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321}.
Top Pathways Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

SYVN1-Over-expression-Lysate - LY11775a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag SYVN1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SYVN1 gene

SYVN1 overexpression lysate - LY406753 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

SYVN1 overexpression lysate - LY410125 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

SYVN1 293 Cell Lysate - 405219 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

SYVN1 293 Cell Lysate - 404020 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg

HRD1 Overexpression Lysate (Native) - NBL1-16659 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: HRD1 Overexpression Lysate (Adult Normal) [NBL1-16659] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HRD1.

HRD1 Overexpression Lysate (Native) - NBL1-16660 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: HRD1 Overexpression Lysate (Adult Normal) [NBL1-16660] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HRD1.

Synoviolin (h2): 293T Lysate - sc-129904 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

Synoviolin (h3): 293T Lysate - sc-170272 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

Synoviolin (h4): 293T Lysate - sc-171048 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

SYVN1 Over-expression Lysate Product - GWB-F07B89 from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

SYVN1 Over-expression Lysate Product - GWB-244780 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

HRD1 Overexpression Lysate (Denatured) - H00084447-T02 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human SYVN1 Knockdown Stable Cell Line - CSC-DC015513 from Creative biogene

Category Cell Line
Species Human
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