SYVN1

Gene Symbol	SYVN1
Entrez Gene	84447
Alt Symbol	DER3, HRD1
Species	Human
Gene Type	protein-coding
Description	synovial apoptosis inhibitor 1, synoviolin
Other Description	E3 ubiquitin-protein ligase synoviolin|HMG-coA reductase degradation 1 homolog
Swissprots	Q86TM6 Q96PK3 Q8N6E8 Q96JL5 Q8N3K3
Accessions	EAW74357 EAW74358 EAW74359 EAW74360 EAW74361 EAW74362 Q86TM6 AA864844 AB058713 BAB47439 AB085847 BAC24801 AF317634 AAL26903 AK074148 BAB84974 AK126912 BAG54394 AL834262 CAD38937 BC013860 BC030530 AAH30530 BC035473 BC141662 AAI41663 DQ574657 EU176276 ABW03727 EU176586 ABW03387 EU446616 ABZ92145 XM_011545303 XP_011543605 NM_032431 NP_115807 NM_172230 NP_757385
Function	Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16289116, ECO:0000269|Pub
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16186510}; Multi- pass membrane protein {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16186510}.
Tissue Specificity	Ubiquitously expressed, with highest levels in liver and kidney (at protein level). Up-regulated in synovial tissues from patients with rheumatoid arthritis (at protein level). {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321}.
Top Pathways	Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SYVN1 protein fragment - ab125740 from Abcam Category Protein Source E. coli Species Human

Human SYVN1 full length protein - ab132449 from Abcam Category Protein Source Wheat germ Species Human

SYVN1 / HRD1 Antibody Blocking Peptide - LS-E15950 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SYVN1 / HRD1 Antibody Blocking Peptide - LS-E15951 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SYVN1 / HRD1 Antibody Blocking Peptide - LS-E29406 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SYVN1 / HRD1 Antibody Blocking Peptide - LS-E6929 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SYVN1 / HRD1 Antibody Blocking Peptide - LS-E6927 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HRD1 Protein - H00084447-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human HRD1 Protein - H00084447-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

HRD1 Peptide - P1015 from Novus Biologicals Category Peptide Species Human

HRD1 Peptide - P1014 from Novus Biologicals Category Peptide Species Human

HRD1-Antibody-N-term-Blocking-Peptide - BP2184e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SYVN1-HRD1-Antibody-Center-R246-Blocking-peptide - BP2184c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SYVN1-HRD1-Antibody-N-term-Blocking-peptide - BP2184b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SYVN1-HRD1-Antibody-C-term-Blocking-peptide - BP2184a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SYVN1 Protein Lysate (APL10241) - APL10241 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SYVN1 Protein Lysate (APL10242) - APL10242 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SYVN1 Protein Lysate (APL10243) - APL10243 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SYVN1 Protein Lysate (APL10515) - APL10515 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SYVN1 Protein Lysate (APL10693) - APL10693 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SYVN1 Blocking Peptide - 33R-7565 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SYVN1 Blocking Peptide - 33R-1484 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SYVN1 - H00084447-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SYVN1 - H00084447-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SYVN1 - H00084447-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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