SYVN1

Gene Symbol	SYVN1
Entrez Gene	84447
Alt Symbol	DER3, HRD1
Species	Human
Gene Type	protein-coding
Description	synovial apoptosis inhibitor 1, synoviolin
Other Description	E3 ubiquitin-protein ligase synoviolin|HMG-coA reductase degradation 1 homolog
Swissprots	Q86TM6 Q96PK3 Q8N6E8 Q96JL5 Q8N3K3
Accessions	EAW74357 EAW74358 EAW74359 EAW74360 EAW74361 EAW74362 Q86TM6 AA864844 AB058713 BAB47439 AB085847 BAC24801 AF317634 AAL26903 AK074148 BAB84974 AK126912 BAG54394 AL834262 CAD38937 BC013860 BC030530 AAH30530 BC035473 BC141662 AAI41663 DQ574657 EU176276 ABW03727 EU176586 ABW03387 EU446616 ABZ92145 XM_011545303 XP_011543605 NM_032431 NP_115807 NM_172230 NP_757385
Function	Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16289116, ECO:0000269|Pub
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16186510}; Multi- pass membrane protein {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16186510}.
Tissue Specificity	Ubiquitously expressed, with highest levels in liver and kidney (at protein level). Up-regulated in synovial tissues from patients with rheumatoid arthritis (at protein level). {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321}.
Top Pathways	Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® SYVN1 siRNA I - 13204 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

Synoviolin CRISPR/Cas9 KO Plasmid (h) - sc-403476 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Synoviolin HDR Plasmid (h) - sc-403476-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Synoviolin Double Nickase Plasmid (h) - sc-403476-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Synoviolin Double Nickase Plasmid (h2) - sc-403476-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Synoviolin CRISPR Activation Plasmid (h) - sc-403476-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Synoviolin CRISPR Activation Plasmid (h2) - sc-403476-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Synoviolin Lentiviral Activation Particles (h) - sc-403476-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Synoviolin Lentiviral Activation Particles (h2) - sc-403476-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Synoviolin siRNA (h) - sc-76620 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Synoviolin shRNA Plasmid (h) - sc-76620-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Synoviolin shRNA (h) Lentiviral Particles - sc-76620-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU060091 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20935 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20935 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08283 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08283

SYVN1 siRNA (Human) - CRJ3479 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HRD1 RNAi - H00084447-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

HRD1 RNAi - H00084447-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

SYVN1 - MBS8205585 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human SYVN1 (NM_172230.2) - SHH422176 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human SYVN1(NM_032431.2) - SHL052344 from Creative biogene Category siRNA Species Reactivities Human

SYVN1 shRNA Plasmid (Human) - CHJ3479 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

SYVN1 miRNA 3'UTR clone - MiUTR1H-10127 from Creative biogene Species Reactivities Human

SYVN1 miRNA 3'UTR clone - MiUTR1H-10128 from Creative biogene Species Reactivities Human

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