SYVN1

Gene Symbol SYVN1
Entrez Gene 84447
Alt Symbol DER3, HRD1
Species Human
Gene Type protein-coding
Description synovial apoptosis inhibitor 1, synoviolin
Other Description E3 ubiquitin-protein ligase synoviolin|HMG-coA reductase degradation 1 homolog
Swissprots Q86TM6 Q96PK3 Q8N6E8 Q96JL5 Q8N3K3
Accessions EAW74357 EAW74358 EAW74359 EAW74360 EAW74361 EAW74362 Q86TM6 AA864844 AB058713 BAB47439 AB085847 BAC24801 AF317634 AAL26903 AK074148 BAB84974 AK126912 BAG54394 AL834262 CAD38937 BC013860 BC030530 AAH30530 BC035473 BC141662 AAI41663 DQ574657 EU176276 ABW03727 EU176586 ABW03387 EU446616 ABZ92145 XM_011545303 XP_011543605 NM_032431 NP_115807 NM_172230 NP_757385
Function Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16289116, ECO:0000269|Pub
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16186510}; Multi- pass membrane protein {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16186510}.
Tissue Specificity Ubiquitously expressed, with highest levels in liver and kidney (at protein level). Up-regulated in synovial tissues from patients with rheumatoid arthritis (at protein level). {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321}.
Top Pathways Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

Human-SYVN1-cDNA-Clone - DC06096 from Abgent, a WuXi AppTec company

Prices $832.95
Sizes 10 µg
Species Human
Accession BC030530

SYVN1 cDNA (ANA10241) - ANA10241 from Aviva Systems Biology

Prices $189.00
Sizes 1 µg
Accession BC030530

SYVN1 cDNA (ANA10242) - ANA10242 from Aviva Systems Biology

Prices $189.00
Sizes 1 µg
Accession BC030530

SYVN1 cDNA (ANA10243) - ANA10243 from Aviva Systems Biology

Prices $189.00
Sizes 1 µg
Accession BC030530

SYVN1 cDNA (ANA10515) - ANA10515 from Aviva Systems Biology

Prices $189.00
Sizes 1 µg
Accession BC030530

SYVN1 cDNA (ANA10693) - ANA10693 from Aviva Systems Biology

Prices $189.00
Sizes 1 µg
Accession NM_172230.2

SYVN1 - MBS1270951 from MyBioSource

Species Human
Accession BC030530

Human SYVN1 cDNA clone(NM_032431.2) - CDFG006055 from Creative Biomart

Species Human
Accession NM_032431.2

Human SYVN1 cDNA clone(NM_032431.2) - CDFG006056 from Creative Biomart

Species Human
Accession NM_032431.2

Human SYVN1 cDNA clone(NM_172230.2) - CDFG010480 from Creative Biomart

Species Human
Accession NM_172230.2

Human SYVN1 ORF Clone(NM_032431.2) - CDCR312325 from Creative Biomart

Species Human
Accession NM_032431.2

Human SYVN1 ORF Clone(NM_032431.2) - CDCR312326 from Creative Biomart

Species Human
Accession NM_032431.2

Human SYVN1 ORF Clone(NM_172230.2) - CDCR321536 from Creative Biomart

Species Human
Accession NM_172230.2

Human SYVN1 ORF Clone(NM_172230.2) - CDCR321537 from Creative Biomart

Species Human
Accession NM_172230.2

Human SYVN1 ORF Clone(NM_172230.2) - CDCR321538 from Creative Biomart

Species Human
Accession NM_172230.2

human SYVN1 ORF clone - CDCH088326 from Creative Biomart

Species Human
Accession NM_032431

human SYVN1 ORF clone - CDCH088327 from Creative Biomart

Species Human
Accession NM_032431

human SYVN1 ORF clone - CDCH088328 from Creative Biomart

Species Human
Accession NM_032431

human SYVN1 ORF clone - CDCH088329 from Creative Biomart

Species Human
Accession NM_032431

Human SYVN1 ORF Clone(NM_032431.2) - CDCL177721 from Creative Biomart

Species Human
Accession NM_032431.2

Human SYVN1 ORF Clone(NM_172230.2) - CDCR321536 from Creative biogene

Species Human

human SYVN1 ORF clone (NM_032431.2) - CDCH088326 from Creative biogene

Species Human

Human SYVN1 ORF Clone (BC030530) - CDCS416277 from Creative biogene

Species Human
Accession Q86TM6

Human SYVN1 cDNA Clone(NM_032431.2) - CDFG006055 from Creative biogene

Species Human

Human SYVN1 cDNA Clone(NM_032431.2) - CDFG006056 from Creative biogene

Species Human
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