TREM2

Gene Symbol	TREM2
Entrez Gene	54209
Alt Symbol	TREM-2, Trem2a, Trem2b, Trem2c
Species	Human
Gene Type	protein-coding
Description	triggering receptor expressed on myeloid cells 2
Other Description	triggering receptor expressed on monocytes 2|triggering receptor expressed on myeloid cells 2a
Swissprots	Q8WYN6 Q9NZC2 Q8N5H8
Accessions	ABB01002 BAJ34724 EAX04032 EAX04033 EAX04034 Q9NZC2 AB062787 BAB78736 AF213457 AAF69824 AK312215 BAG35148 BC018284 BC032362 AAH32362 DQ891310 ABM82236 DQ894494 ABM85420 XM_006715116 XP_006715179 NM_001271821 NP_001258750 NM_018965 NP_061838
Function	May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. {ECO:0000269|PubMed:10799849}.
Subcellular Location	Isoform 3: Secreted {ECO:0000305}.
Tissue Specificity	Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord. {ECO:0000269|PubMed:10799849, ECO:0000269|PubMed:12080485}.
Top Pathways	Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TREM2 full length protein - ab153366 from Abcam Category Protein Source Wheat germ Species Human

Human TREM2 protein fragment - ab174422 from Abcam Category Protein Source E. coli Species Human

TREM2 / TREM-2 Antibody Blocking Peptide - LS-E6508 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TREM2 / TREM-2 Antibody Blocking Peptide - LS-E7849 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TREM2 / TREM-2 Antibody Blocking Peptide - LS-E26400 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TREM-2 Recombinant Protein - H00054209-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human TREM-2 Protein - NBP2-22888 from Novus Biologicals Category Protein Prices $269.00 Sizes 50 µg Species Human

TREM2-Antibody-N-term-Blocking-peptide - BP5469a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TREM2 blocking peptide - GTX89017-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human TREM-2 Fc Chimera, CF - 1828-T2-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human TREM-2 protein - orb83357 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Goat anti TREM2 antibody Immunizing peptide - orb16853 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

TREM2 Blocking Peptide - 33R-3016 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TREM2 protein (His tag) - 80R-3585 from Fitzgerald Category Protein Prices $295.00 Sizes 50 µg Source E.coli

TREM2 Peptide - AC21-1238-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TREM2 (19-161, His-tag) - AR51272PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

TREM2 (19-161, His-tag) - AR51272PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

TREM2 - H00054209-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TREM2 - H00054209-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TREM2, 19-161aa, Human, His tag, E.coli - 01-P2452 from ARP American Research Products Category Protein Prices $149.00, $369.00, $849.00 Sizes 10 µg, 50 µg, 250 µg Species Human

TREM2 Peptide - 46-513P from ProSci Category Peptide Species Human

TREM2 fusion protein - ag6843 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

TREM2 fusion protein - Ag4299 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Mouse Trem2, His-tagged - Trem2-3276M from Creative Biomart Category Protein Source Human Cells .

Recombinant Human TREM2, His tagged - TREM2-3111H from Creative Biomart Category Protein Source Human Cells Species Human

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