TREM2

Gene Symbol TREM2
Entrez Gene 54209
Alt Symbol TREM-2, Trem2a, Trem2b, Trem2c
Species Human
Gene Type protein-coding
Description triggering receptor expressed on myeloid cells 2
Other Description triggering receptor expressed on monocytes 2|triggering receptor expressed on myeloid cells 2a
Swissprots Q8WYN6 Q9NZC2 Q8N5H8
Accessions ABB01002 BAJ34724 EAX04032 EAX04033 EAX04034 Q9NZC2 AB062787 BAB78736 AF213457 AAF69824 AK312215 BAG35148 BC018284 BC032362 AAH32362 DQ891310 ABM82236 DQ894494 ABM85420 XM_006715116 XP_006715179 NM_001271821 NP_001258750 NM_018965 NP_061838
Function May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. {ECO:0000269|PubMed:10799849}.
Subcellular Location Isoform 3: Secreted {ECO:0000305}.
Tissue Specificity Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord. {ECO:0000269|PubMed:10799849, ECO:0000269|PubMed:12080485}.
Top Pathways Osteoclast differentiation

TREM-2 (B-3) - sc-373828 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TREM-2 (B-3): sc-373828. Western blot analysis of TREM-2 expression in non-transfected (A) and human TREM-2 transfected (B) whole cell lysates.

TREM-2 (E-20) - sc-22633 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TREM-2 (H-160) - sc-48764 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TREM-2 (H-160): sc-48764. Western blot analysis of TREM-2 expression in non-transfected (A) and human TREM-2 transfected (B) whole cell lysates.

Anti-TREM2 antibody - ab85851 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab85851 at 2.5 µg/ml staining TREM2 in Human Spleen macrophages in formalin fixed, paraffin embedded tissue.

Anti-TREM2 antibody [MM0942-42E14] - ab201621 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0942-42E14

Anti-TREM2 antibody [RM0139-5J46] - ab86491 from Abcam

Prices $376.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone RM0139-5J46
IHC-Fr image of human blood vessels stained with Ab86491 (1:250). The fixed brain sections were permeabilized using 0.1% PBS-Triton X for 1h. 10% donkey serum was used for 1 hour at 24°C to block protein-protein interactions.  The sections were then incubated with Ab8649 used at 1/250 dilution, overnight at +4°C. The secondary antibody was Alexa Fluor® 568 donkey anti-rat used at 1/1000 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.See Abreview

Anti-TREM2 antibody - N-terminal - ab175262 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TREM2 antibody - N-terminal (ab175262) at 1/100 dilution + MDA-MB435 cell lysate at 35 µg

Anti-TREM2 / TREM-2 Antibody (clone 6E9) - LS-C210258 from LifeSpan Bioscience

Prices $420.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 6E9

Anti-TREM2 / TREM-2 Antibody (aa22-48, AP) - LS-C272138 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TREM2 / TREM-2 Antibody (aa22-48, APC) - LS-C272139 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TREM2 / TREM-2 Antibody (aa143-192) - LS-C116365 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TREM2 antibody LS-C116365 Western blot of Fetal Muscle lysate.

Anti-TREM2 / TREM-2 Antibody (clone 78.18, FITC) - LS-C188611 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 78.18
J774 cells stained with Rat anti-Mouse TREM2:FITC

Anti-TREM2 / TREM-2 Antibody (aa22-48, Biotin) - LS-C272140 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TREM2 / TREM-2 Antibody (aa22-48, PE) - LS-C272143 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TREM2 / TREM-2 Antibody (aa22-48, Azide-free, HRP) - LS-C272142 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TREM2 / TREM-2 Antibody (aa29-59, AP) - LS-C272144 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TREM2 / TREM-2 Antibody (aa19-174) - LS-C150090 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
TREM-2 in Human Dendritic Cells. TREM-2 was detected in immersion fixed immature human dendritic cells using Goat Anti-Human TREM-2 Antigen Affinity-purified Polyclonal Antibody at 10 ug/ml for 3 hours at room temperature. Cells were stained using NorthernLights 557-conjugated Anti-Goat IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm.

Anti-TREM2 / TREM-2 Antibody (aa154-165) - LS-C108118 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
TREM2 antibody (0.3 ug/ml) staining of Mouse Liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-TREM2 / TREM-2 Antibody (aa22-48, FITC) - LS-C272141 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TREM2 / TREM-2 Antibody (aa29-59, Biotin) - LS-C272146 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TREM2 / TREM-2 Antibody (aa29-59, APC) - LS-C272145 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TREM2 / TREM-2 Antibody (aa29-59, FITC) - LS-C272147 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TREM2 / TREM-2 Antibody (aa29-59, Azide-free, HRP) - LS-C272148 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TREM2 / TREM-2 Antibody (aa22-50) - LS-C160170 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TREM2 Antibody western blot of MDA-MB435 cell line lysates (35 ug/lane). The TREM2 antibody detected the TREM2 protein (arrow).

Anti-TREM2 / TREM-2 Antibody (aa29-59, PE) - LS-C272149 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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