| Gene Symbol |
TREM2
|
| Entrez Gene |
54209
|
| Alt Symbol |
TREM-2, Trem2a, Trem2b, Trem2c
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
triggering receptor expressed on myeloid cells 2
|
| Other Description |
triggering receptor expressed on monocytes 2|triggering receptor expressed on myeloid cells 2a
|
| Swissprots |
Q8WYN6 Q9NZC2 Q8N5H8
|
| Accessions |
ABB01002 BAJ34724 EAX04032 EAX04033 EAX04034 Q9NZC2 AB062787 BAB78736 AF213457 AAF69824 AK312215 BAG35148 BC018284 BC032362 AAH32362 DQ891310 ABM82236 DQ894494 ABM85420 XM_006715116 XP_006715179 NM_001271821 NP_001258750 NM_018965 NP_061838
|
| Function |
May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. {ECO:0000269|PubMed:10799849}.
|
| Subcellular Location |
Isoform 3: Secreted {ECO:0000305}.
|
| Tissue Specificity |
Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord. {ECO:0000269|PubMed:10799849, ECO:0000269|PubMed:12080485}.
|
| Top Pathways |
Osteoclast differentiation
|
![Western Blot: TREM2 Overexpression Lysate (Adult Normal) [NBP2-06751] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TREM2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4945_TREM2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06751-img0001.jpg)