TNFSF11

Gene Symbol TNFSF11
Entrez Gene 8600
Alt Symbol CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf
Species Human
Gene Type protein-coding
Description tumor necrosis factor (ligand) superfamily, member 11
Other Description TNF-related activation-induced cytokine|osteoclast differentiation factor|osteoprotegerin ligand|receptor activator of nuclear factor kappa B ligand|receptor activator of nuclear factor kappa-B ligand|tumor necrosis factor ligand superfamily member 11
Swissprots Q9P2Q3 O14723 Q96Q17 O14788
Accessions CAJ09926 CAX24322 EAX08679 EAX08680 EAX08681 O14788 AA504211 AB037599 BAA90488 AB061227 BAB71768 AB064268 BAB79693 AB064269 BAB79694 AB064270 BAB79695 AF013171 AAC51762 AF019047 AAB86811 AF053712 AAC39731 BC040889 BC074823 AAH74823 BC074890 AAH74890 BC117286 AAI17287 BC117288 AAI17289 BQ007726 HQ258604 ADR83357 XM_011535280 XP_011533582 NM_003701 NP_003692 NM_033012 NP_143026
Function Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. {ECO:0000269|PubMed:22664871}.
Subcellular Location Isoform 2: Cytoplasm {ECO:0000250}.
Tissue Specificity Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.
Top Pathways Cytokine-cytokine receptor interaction, Osteoclast differentiation, Rheumatoid arthritis, Prolactin signaling pathway

RANKL CRISPR/Cas9 KO Plasmid (h) - sc-400304 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RANKL HDR Plasmid (h) - sc-400304-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RANKL Double Nickase Plasmid (h) - sc-400304-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RANKL Double Nickase Plasmid (h2) - sc-400304-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RANKL CRISPR Activation Plasmid (h) - sc-400304-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RANKL CRISPR Activation Plasmid (h2) - sc-400304-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RANKL Lentiviral Activation Particles (h) - sc-400304-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RANKL Lentiviral Activation Particles (h2) - sc-400304-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RANKL siRNA (h) - sc-29464 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RANKL shRNA Plasmid (h) - sc-29464-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RANKL shRNA (h) Lentiviral Particles - sc-29464-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRANCE/TNFSF11/RANK L RNAi - H00008600-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU061701 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21760 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21760 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08031 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08031

TNFSF11 siRNA (Human) - CRH5648 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRANCE/TNFSF11/RANK L RNAi - H00008600-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

TNFSF11 - MBS8215366 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TNFSF11 (NM_003701.3) - SHH432100 from Creative biogene

Category siRNA
Species Reactivities Human

TNFSF11 shRNA Plasmid (Human) - CHH5648 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TNFSF11 miRNA 3'UTR clone - MiUTR3H-05165 from Creative biogene

Species Reactivities Human

TNFSF11 miRNA 3'UTR clone - MiUTR3H-05166 from Creative biogene

Species Reactivities Human
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