TNFSF11

Gene Symbol	TNFSF11
Entrez Gene	8600
Alt Symbol	CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 11
Other Description	TNF-related activation-induced cytokine|osteoclast differentiation factor|osteoprotegerin ligand|receptor activator of nuclear factor kappa B ligand|receptor activator of nuclear factor kappa-B ligand|tumor necrosis factor ligand superfamily member 11
Swissprots	Q9P2Q3 O14723 Q96Q17 O14788
Accessions	CAJ09926 CAX24322 EAX08679 EAX08680 EAX08681 O14788 AA504211 AB037599 BAA90488 AB061227 BAB71768 AB064268 BAB79693 AB064269 BAB79694 AB064270 BAB79695 AF013171 AAC51762 AF019047 AAB86811 AF053712 AAC39731 BC040889 BC074823 AAH74823 BC074890 AAH74890 BC117286 AAI17287 BC117288 AAI17289 BQ007726 HQ258604 ADR83357 XM_011535280 XP_011533582 NM_003701 NP_003692 NM_033012 NP_143026
Function	Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. {ECO:0000269|PubMed:22664871}.
Subcellular Location	Isoform 2: Cytoplasm {ECO:0000250}.
Tissue Specificity	Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.
Top Pathways	Cytokine-cytokine receptor interaction, Osteoclast differentiation, Rheumatoid arthritis, Prolactin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RANKL (TNFSF11) Mouse ELISA Kit - ab100749 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 4 pg/ml Range 2.74 pg/ml - 2000 pg/ml

TNFSF11/RANKL BioAssay™ ELISA Kit, Mouse - 144077 from USBiological Life Science Category ELISA Kit Sensitivity < 10 pg/ml Range 62.5pg/ml-4000pg/ml

TRANCE/TNFSF11/RANK L, Human, BioAssay™ DuoSet ELISA Development Kit (CD254, RANK L,TNFSF11) - 145772 from USBiological Life Science Range 78.1-5000pg/ml

Rat TNFSF11 / RANKL / TRANCE ELISA Kit (Sandwich ELISA) - LS-F5673 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 5.5 pg/ml Range 2.743-666.7 pg/ml

Human TNFSF11 / RANKL / TRANCE ELISA Kit (Sandwich ELISA) - LS-F5672 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.058 ng/ml Range 2.743-666.7 pg/ml

Mouse TNFSF11 / RANKL / TRANCE ELISA Kit (Sandwich ELISA) - LS-F5674 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 3.1 pg/ml Range 2.743-666.7 pg/ml

Mouse/Human TNFSF11 / RANKL / TRANCE ELISA Kit (Cell-Based ELISA) - LS-F3001 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 2.743-666.7 pg/ml

Mouse TNFSF11 / RANKL / TRANCE ELISA Kit (Sandwich ELISA) - LS-F297 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 2.743 pg/ml Range 2.743-666.7 pg/ml

Human TNFSF11 / RANKL / TRANCE ELISA Kit (Sandwich ELISA) - LS-F2712 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 78 pg/ml Range 2.743-666.7 pg/ml

Mouse TNFSF11 / RANKL / TRANCE ELISA Kit (Sandwich ELISA) - LS-F2713 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 2.743-666.7 pg/ml

Human TNFSF11 / RANKL / TRANCE ELISA Kit (Sandwich ELISA) - LS-F12792 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 2.743-666.7 pg/ml

Rat TNFSF11 / RANKL / TRANCE ELISA Kit (Sandwich ELISA) - LS-F12790 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 7.8 Range 2.743-666.7 pg/ml

Mouse TNFSF11 / RANKL / TRANCE ELISA Kit (Sandwich ELISA) - LS-F12791 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 15.6 Range 2.743-666.7 pg/ml

Mouse TRANCE/RANK L/TNFSF11 Quantikine ELISA Kit - MTR00 from R&D Systems Category ELISA Kit Prices $479.00 Sizes 1 kit Sensitivity 5 pg/mL Range 31.2 - 2,000 pg/mL (Cell Culture Supernates, Serum)

Mouse TRANCE/RANK L/TNFSF11 DuoSet ELISA - DY462 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 4,000 pg/mL

Human TRANCE/RANK L/TNFSF11 DuoSet ELISA - DY626 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 78.10 - 5,000 pg/mL

Mouse RANKL ELISA Kit - 55R-MRANKL-KT from Fitzgerald Category ELISA Kit Prices $465.00 Sizes 1 kit

Human CD254 ELISA Kit - abx056082 from Abbexa Category ELISA Kit

Human Osteoprotegerin Ligand ELISA Kit - abx055395 from Abbexa Category ELISA Kit

Osteoclast Differentiation Factor, ODF, Human, ELISA Kit - E-EL-H1594 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

OPGL (Osteoprotegerin Ligand), Human, ELISA Kit - E-EL-H1342 from ARP American Research Products Category ELISA Kit Prices $617.40 Sizes 96 t

Receptor Activator of Nuclear Factor Kappa B Ligand, RANkL, Human, ELISA Kit - E-EL-H1387 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL), Human, ELISA Kit - SEA855Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.056ng/mL Range 0.156-10ng/mL

Soluble receptor activator of nuclear factor-kB ligand, sRANKL, Human, ELISA Kit - CSB-E05125h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 1.95 pg/ml Range 7.8 pg/ml-500 pg/ml

Tumor necrosis factor ligand superfamily member 11, TNFSF11, Human, ELISA Kit - E0855h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

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