TNFSF11

Gene Symbol	TNFSF11
Entrez Gene	8600
Alt Symbol	CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 11
Other Description	TNF-related activation-induced cytokine|osteoclast differentiation factor|osteoprotegerin ligand|receptor activator of nuclear factor kappa B ligand|receptor activator of nuclear factor kappa-B ligand|tumor necrosis factor ligand superfamily member 11
Swissprots	Q9P2Q3 O14723 Q96Q17 O14788
Accessions	CAJ09926 CAX24322 EAX08679 EAX08680 EAX08681 O14788 AA504211 AB037599 BAA90488 AB061227 BAB71768 AB064268 BAB79693 AB064269 BAB79694 AB064270 BAB79695 AF013171 AAC51762 AF019047 AAB86811 AF053712 AAC39731 BC040889 BC074823 AAH74823 BC074890 AAH74890 BC117286 AAI17287 BC117288 AAI17289 BQ007726 HQ258604 ADR83357 XM_011535280 XP_011533582 NM_003701 NP_003692 NM_033012 NP_143026
Function	Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. {ECO:0000269|PubMed:22664871}.
Subcellular Location	Isoform 2: Cytoplasm {ECO:0000250}.
Tissue Specificity	Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.
Top Pathways	Cytokine-cytokine receptor interaction, Osteoclast differentiation, Rheumatoid arthritis, Prolactin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human RANKL protein fragment - ab157289 from Abcam Category Protein Prices $465.00 Sizes 10 µg Source HEK 293 cells Species Human

Active mouse RANKL protein fragment - ab129136 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Mouse

Active RANKL full length protein - ab9958 from Abcam Category Protein Prices $257.00 Sizes 10 µg Source E. coli

Active rat sRANKL full length protein - ab69517 from Abcam Category Protein Prices $110.00, $257.00 Sizes 2 µg, 10 µg Source E. coli Species Rat

Human RANKL peptide - ab104698 from Abcam Category Peptide

Human sRANKL full length protein - ab108129 from Abcam Category Protein Source E. coli Species Human

Mouse RANKL full length protein - ab151200 from Abcam Category Protein Source Yeast Species Mouse

Mouse RANKL full length protein - ab51941 from Abcam Category Protein Source E. coli Species Mouse

Rat RANKL protein fragment - ab177580 from Abcam Category Protein Source Yeast Species Rat

sRANKL peptide - ab66423 from Abcam Category Peptide

TNFSF11 / RANKL / TRANCE Antibody Blocking Peptide - LS-E30281 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TNFSF11 / RANKL / TRANCE Antibody Blocking Peptide - LS-E9839 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TRANCE/TNFSF11/RANK L Protein - NBP1-72339 from Novus Biologicals Category Protein Prices $299.00, $749.00 Sizes 100 µg, 500 µg Source E. coli Species Human

TRANCE/TNFSF11/RANK L Recombinant Protein - H00008600-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TRANCE/TNFSF11/RANK L Partial Recombinant Protein - H00008600-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TRANCE/TNFSF11/RANK L Recombinant Protein - P4051 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TRANCE/TNFSF11/RANK L Recombinant Protein - P4434 from Novus Biologicals Category Protein Prices $549.00 Sizes 10 µg Species Human

TRANCE/TNFSF11/RANK L Blocking Peptide - NBP1-76734PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Human TRANCE/TNFSF11/RANK L Protein - NBP1-99308 from Novus Biologicals Category Protein Prices $529.00 Sizes 50 µg Source E. coli Species Human

TRANCE/TNFSF11/RANK L Protein - NBP1-99677 from Novus Biologicals Category Protein Species Human

Recombinant TRANCE/TNFSF11/RANK L Protein - NBP1-43167 from Novus Biologicals Category Protein Prices $249.00, $349.00 Sizes 5 µg, 25 µg

TRANCE/TNFSF11/RANK L Recombinant Protein - H00008600-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

TNFSF11-Antibody-N-term-Blocking-Peptide - BP8895a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RANK (sRANKL) recombinant protein - GTX65292 from GeneTex Category Protein Prices $249.00 Sizes 10 μg Source E. coli Species Human

RANK (sRANKL) recombinant protein - GTX65291 from GeneTex Category Protein Prices $519.00 Sizes 50 μg Source E. coli Species Human

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