| Gene Symbol | TNFSF11 |
|---|---|
| Entrez Gene | 8600 |
| Alt Symbol | CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf |
| Species | Human |
| Gene Type | protein-coding |
| Description | tumor necrosis factor (ligand) superfamily, member 11 |
| Other Description | TNF-related activation-induced cytokine|osteoclast differentiation factor|osteoprotegerin ligand|receptor activator of nuclear factor kappa B ligand|receptor activator of nuclear factor kappa-B ligand|tumor necrosis factor ligand superfamily member 11 |
| Swissprots | Q9P2Q3 O14723 Q96Q17 O14788 |
| Accessions | CAJ09926 CAX24322 EAX08679 EAX08680 EAX08681 O14788 AA504211 AB037599 BAA90488 AB061227 BAB71768 AB064268 BAB79693 AB064269 BAB79694 AB064270 BAB79695 AF013171 AAC51762 AF019047 AAB86811 AF053712 AAC39731 BC040889 BC074823 AAH74823 BC074890 AAH74890 BC117286 AAI17287 BC117288 AAI17289 BQ007726 HQ258604 ADR83357 XM_011535280 XP_011533582 NM_003701 NP_003692 NM_033012 NP_143026 |
| Function | Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. {ECO:0000269|PubMed:22664871}. |
| Subcellular Location | Isoform 2: Cytoplasm {ECO:0000250}. |
| Tissue Specificity | Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid. |
| Top Pathways | Cytokine-cytokine receptor interaction, Osteoclast differentiation, Rheumatoid arthritis, Prolactin signaling pathway |