TNFSF11

Gene Symbol	TNFSF11
Entrez Gene	8600
Alt Symbol	CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 11
Other Description	TNF-related activation-induced cytokine|osteoclast differentiation factor|osteoprotegerin ligand|receptor activator of nuclear factor kappa B ligand|receptor activator of nuclear factor kappa-B ligand|tumor necrosis factor ligand superfamily member 11
Swissprots	Q9P2Q3 O14723 Q96Q17 O14788
Accessions	CAJ09926 CAX24322 EAX08679 EAX08680 EAX08681 O14788 AA504211 AB037599 BAA90488 AB061227 BAB71768 AB064268 BAB79693 AB064269 BAB79694 AB064270 BAB79695 AF013171 AAC51762 AF019047 AAB86811 AF053712 AAC39731 BC040889 BC074823 AAH74823 BC074890 AAH74890 BC117286 AAI17287 BC117288 AAI17289 BQ007726 HQ258604 ADR83357 XM_011535280 XP_011533582 NM_003701 NP_003692 NM_033012 NP_143026
Function	Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. {ECO:0000269|PubMed:22664871}.
Subcellular Location	Isoform 2: Cytoplasm {ECO:0000250}.
Tissue Specificity	Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.
Top Pathways	Cytokine-cytokine receptor interaction, Osteoclast differentiation, Rheumatoid arthritis, Prolactin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CD254 / RANKL Lysate(Denatured) - H00008600-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

TNFSF11 293 Cell Lysate - 401126 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Disease Tumor

TNFSF11 293 Cell Lysate - 402796 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Disease Tumor

TRANCE/TNFSF11/RANK L Overexpression Lysate (Denatured) - H00008600-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

TRANCE/TNFSF11/RANK L Overexpression Lysate (Native) - NBL1-17163 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

TRANCE/TNFSF11/RANK L Overexpression Lysate (Native) - NBL1-17162 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

TNFSF11 Over-expression Lysate Product - GWB-CB20DD from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

TNFSF11 Over-expression Lysate Product - GWB-8B4998 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Cynomolgus RANKL / OPGL / TNFSF11 HEK293 Cell Lysate (WB positive control) - 90301-C01HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Human RANKL / OPGL / TNFSF11 / CD254 HEK293 Cell Lysate (WB positive control) - 11682-HNCHL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human RANKL / OPGL / TNFSF11 / CD254 HEK293 Cell Lysate (WB positive control) - 11682-H15HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human RANKL / OPGL / TNFSF11 / CD254 HEK293 Cell Lysate (WB positive control) - 11682-H04HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human RANKL / OPGL / TNFSF11 / CD254 HEK293 Cell Lysate (WB positive control) - 11682-H01HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Panoply™ Human TNFSF11 Knockdown Stable Cell Line - CSC-DC016372 from Creative biogene Category Cell Line Species Human

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