CTCF

Gene Symbol	CTCF
Entrez Gene	10664
Alt Symbol	MRD21
Species	Human
Gene Type	protein-coding
Description	CCCTC-binding factor (zinc finger protein)
Other Description	11 zinc finger transcriptional repressor|11-zinc finger protein|CTCFL paralog|transcriptional repressor CTCF
Swissprots	Q59EL8 Q53XI7 B5MC38 P49711
Accessions	AAF31318 CAH05607 EAW83142 EAW83143 EAW83144 EAW83145 EAW83146 P49711 AA814313 AB209793 BAD93030 AI753629 AK093395 BAG52706 AK314804 BC014267 AAH14267 BT009915 AAP88917 DB229066 DQ895834 ABM86760 EU176369 ABW03820 U25435 AAB07788 XM_005255775 XP_005255832 NM_001191022 NP_001177951 NM_006565 NP_006556
Function	Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over
Subcellular Location	Nucleus, nucleoplasm. Chromosome. Chromosome, centromere. Note=May translocate to the nucleolus upon cell differentiation. Associates with both centromeres and chromosomal arms during metaphase. Associates with the H19 ICR in mitotic chromosomes. May be preferentially excluded from heterochromatin during interphase.
Tissue Specificity	Ubiquitous. Absent in primary spermatocytes. {ECO:0000269|PubMed:9591631}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CTCF full length protein - ab153114 from Abcam Category Protein Source Wheat germ Species Human

Human CTCF protein fragment - ab112395 from Abcam Category Protein Source Wheat germ Species Human

Human CTCF protein fragment - ab173020 from Abcam Category Protein Source E. coli Species Human

CTCF Antibody Blocking Peptide - LS-E10816 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CTCF Antibody Blocking Peptide - LS-E10817 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CTCF Antibody Blocking Peptide - LS-E13984 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CTCF Protein - H00010664-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Human CTCF R protein - orb163462 from Biorbyt Category Protein Prices $408.00, $595.00, $2,074.00, $2,933.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source E. coli Species Human

CTCF - H00010664-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

CTCF - H00010664-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CTCF - H00010664-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CTCF, Human, Recombinant - 19-CF20 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

CTCF fusion protein - ag1340 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CTCF Protein - BP002607-CF20 from Syd Labs Category Protein Prices $180.00, $528.00, $2,880.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human CTCF - CTCF-26436TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Transcriptional repressor CTCF(CTCF) - CSB-YP006138HU CSB-EP006138HU CSB-BP006138HU CSB-MP006138HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human CTCF Protein - H00010664-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

CTCF-Blocking-Peptide-Center - BP21506c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CTCF-Blocking-Peptide-N-Term - BP21499a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CTCF Peptide, Human - M34GP03786H from Creative Peptides Category Peptide Source Synthetic. Species Human

Transcriptional repressor CTCF (102-110) - ta-078 from Creative Peptides Category Peptide Source Homo sapiens (human)

CTCF Recombinant Protein (OPCA02634) - OPCA02634 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Human CTCF protein - orb358233 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

CTCF Recombinant Protein Antigen - NBP2-33854PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

Recombinant Homo sapiens Transcriptional repressor CTCF - AP72515 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source Yeast

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