| Gene Symbol |
CTCF
|
| Entrez Gene |
10664
|
| Alt Symbol |
MRD21
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CCCTC-binding factor (zinc finger protein)
|
| Other Description |
11 zinc finger transcriptional repressor|11-zinc finger protein|CTCFL paralog|transcriptional repressor CTCF
|
| Swissprots |
Q59EL8 Q53XI7 B5MC38 P49711
|
| Accessions |
AAF31318 CAH05607 EAW83142 EAW83143 EAW83144 EAW83145 EAW83146 P49711 AA814313 AB209793 BAD93030 AI753629 AK093395 BAG52706 AK314804 BC014267 AAH14267 BT009915 AAP88917 DB229066 DQ895834 ABM86760 EU176369 ABW03820 U25435 AAB07788 XM_005255775 XP_005255832 NM_001191022 NP_001177951 NM_006565 NP_006556
|
| Function |
Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over
|
| Subcellular Location |
Nucleus, nucleoplasm. Chromosome. Chromosome, centromere. Note=May translocate to the nucleolus upon cell differentiation. Associates with both centromeres and chromosomal arms during metaphase. Associates with the H19 ICR in mitotic chromosomes. May be preferentially excluded from heterochromatin during interphase.
|
| Tissue Specificity |
Ubiquitous. Absent in primary spermatocytes. {ECO:0000269|PubMed:9591631}.
|