RPS6KB1

Gene Symbol	RPS6KB1
Entrez Gene	6198
Alt Symbol	PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha
Species	Human
Gene Type	protein-coding
Description	ribosomal protein S6 kinase, 70kDa, polypeptide 1
Other Description	p70 S6 kinase, alpha|ribosomal protein S6 kinase I|ribosomal protein S6 kinase beta-1|serine/threonine kinase 14 alpha|serine/threonine-protein kinase 14A
Swissprots	F6UYM1 E7ESB8 B4DTG1 B4DLT4 Q7Z721 B2R779 P23443
Accessions	CAM82744 CDL93497 EAW94382 EAW94383 EAW94384 P23443 AA424792 AI806441 AK026730 AK091503 AK293247 BAG56781 AK297147 BAG59646 AK300202 BAG61973 AK312875 BAG35726 BC030763 BC036033 AAH36033 BC053365 AAH53365 BG614269 BP359158 BQ719717 CA444907 CB050838 M60724 AAA36410 XM_006722010 XP_006722073 XM_011525101 XP_011523403 XM_011525102 XP_011523404 XM_011525103 XP_011523405 XM_011525104 XP_011523406 NM_001272042 NP_001258971 NM_001272043 NP_001258972 NM_001272044 NP_001258973 NM_001272060 NP_001258989 NM_003161 NP_003152
Function	Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein
Subcellular Location	Isoform Alpha II: Cytoplasm.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:9804755}.
Top Pathways	Fc gamma R-mediated phagocytosis, Proteoglycans in cancer, Choline metabolism in cancer, AMPK signaling pathway, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RPS6KB1 - MBS1269434 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC053365

Human RPS6KB1 cDNA clone(NM_003161.2) - CDFH016690 from Creative Biomart Species Human Accession NM_003161.2

Human RPS6KB1 cDNA clone(NM_003161.2) - CDFH016691 from Creative Biomart Species Human Accession NM_003161.2

Human RPS6KB1 cDNA clone(NM_003161.2) - CDFH016692 from Creative Biomart Species Human Accession NM_003161.2

Human RPS6KB1 cDNA clone(NM_003161.2) - CDFH016693 from Creative Biomart Species Human Accession NM_003161.2

Human RPS6KB1 cDNA clone(NM_003161.2) - CDFH016694 from Creative Biomart Species Human Accession NM_003161.2

Human RPS6KB1 ORF clone(NM_003161.2) - CDCL186009 from Creative Biomart Species Human Accession NM_003161.2

Human RPS6KB1 ORF Clone(NM_003161.2) - CDCL174235 from Creative Biomart Species Human Accession NM_003161.2

Human RPS6KB1 ORF Clone(NM_003161.2) - CDCR285028 from Creative Biomart Species Human Accession NM_003161.2

Human RPS6KB1 ORF Clone(NM_003161.2) - CDCR285029 from Creative Biomart Species Human Accession NM_003161.2

Human RPS6KB1 ORF Clone(NM_003161.2) - CDCR285030 from Creative Biomart Species Human Accession NM_003161.2

Human PS6K / RPS6KB1 Gene ORF cDNA clone in cloning vector - HG10099-M from Sino Biological Species Human

Human S6K / RPS6KB1 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG10099-M-F from Sino Biological Species Human Accession NM_003161.2

Human S6K / RPS6KB1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG10099-M-N from Sino Biological Species Human Accession NM_003161.2

Human PS6K / RPS6KB1 Gene ORF cDNA clone expression plasmid - HG10099-UT from Sino Biological Species Human

Human PS6K / RPS6KB1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10099-CY from Sino Biological Species Human

Human PS6K / RPS6KB1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10099-CH from Sino Biological Species Human

Human PS6K / RPS6KB1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10099-NF from Sino Biological Species Human

Human PS6K / RPS6KB1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10099-CF from Sino Biological Species Human

Human PS6K / RPS6KB1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10099-NY from Sino Biological Species Human

Human PS6K / RPS6KB1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10099-ACG from Sino Biological Species Human

Human PS6K / RPS6KB1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10099-NM from Sino Biological Species Human

Human PS6K / RPS6KB1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10099-CM from Sino Biological Species Human

Human PS6K / RPS6KB1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10099-ANG from Sino Biological Species Human

Human PS6K / RPS6KB1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10099-NH from Sino Biological Species Human

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