| Gene Symbol | RPS6KB1 |
|---|---|
| Entrez Gene | 6198 |
| Alt Symbol | PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha |
| Species | Human |
| Gene Type | protein-coding |
| Description | ribosomal protein S6 kinase, 70kDa, polypeptide 1 |
| Other Description | p70 S6 kinase, alpha|ribosomal protein S6 kinase I|ribosomal protein S6 kinase beta-1|serine/threonine kinase 14 alpha|serine/threonine-protein kinase 14A |
| Swissprots | F6UYM1 E7ESB8 B4DTG1 B4DLT4 Q7Z721 B2R779 P23443 |
| Accessions | CAM82744 CDL93497 EAW94382 EAW94383 EAW94384 P23443 AA424792 AI806441 AK026730 AK091503 AK293247 BAG56781 AK297147 BAG59646 AK300202 BAG61973 AK312875 BAG35726 BC030763 BC036033 AAH36033 BC053365 AAH53365 BG614269 BP359158 BQ719717 CA444907 CB050838 M60724 AAA36410 XM_006722010 XP_006722073 XM_011525101 XP_011523403 XM_011525102 XP_011523404 XM_011525103 XP_011523405 XM_011525104 XP_011523406 NM_001272042 NP_001258971 NM_001272043 NP_001258972 NM_001272044 NP_001258973 NM_001272060 NP_001258989 NM_003161 NP_003152 |
| Function | Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein |
| Subcellular Location | Isoform Alpha II: Cytoplasm. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:9804755}. |
| Top Pathways | Fc gamma R-mediated phagocytosis, Proteoglycans in cancer, Choline metabolism in cancer, AMPK signaling pathway, PI3K-Akt signaling pathway |
PathScan ® Phospho-p70 S6 Kinase (Thr389) Chemiluminescent Sandwich ELISA Kit - 7153 from Cell Signaling Technology
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PathScan ® Phospho-p70 S6 Kinase (Thr389) Sandwich ELISA Antibody Pair - 7053 from Cell Signaling Technology
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PathScan ® Phospho-p70 S6 Kinase (Thr389) Sandwich ELISA Kit - 7063 from Cell Signaling Technology
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PathScan ® Total p70 S6 Kinase Sandwich ELISA Kit - 7038 from Cell Signaling Technology
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PathScan® Total p70 S6 Kinase Sandwich ELISA Antibody Pair - 7039 from Cell Signaling Technology
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Mouse/Human/Rat Phospho-RPS6KB1 / P70S6K / S6K (Thr229) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1197 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-RPS6KB1 / P70S6K / S6K (Ser371) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1198 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-RPS6KB1 / P70S6K / S6K (Ser418) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1199 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-RPS6KB1 / P70S6K / S6K (Ser411) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1597 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-RPS6KB1 / P70S6K / S6K (Ser424) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1598 from LifeSpan Bioscience
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Mouse/Human/Rat RPS6KB1 / P70S6K / S6K ELISA Kit (Cell-Based ELISA) - LS-F2215 from LifeSpan Bioscience
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Human RPS6KB1 / P70S6K / S6K ELISA Kit (Sandwich ELISA) - LS-F7827 from LifeSpan Bioscience
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Human/Mouse Phospho-p70 S6 Kinase (T389) Cell-Based ELISA - KCB8963 from R&D Systems
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Phospho-p70 S6 Kinase (T389) DuoSet IC ELISA - DYC896-2 from R&D Systems
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Phospho-p70 S6 Kinase (T389) DuoSet IC, 5 Plate - DYC896-5 from R&D Systems
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Phospho-p70 S6 Kinase (T421/S424) DuoSet IC ELISA, 2 Plate - DYC8965-2 from R&D Systems
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Human/Mouse/Rat Total p70 S6 Kinase DuoSet IC ELISA, 2 Plate - DYC8962-2 from R&D Systems
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Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1), Human, ELISA Kit - SEL979Hu from ARP American Research Products
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Ribosomal protein S6 kinase beta-1 (RPS6KB1), Human, ELISA Kit - CSB-EL020470HU from ARP American Research Products
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Ribosomal Protein S6 Kinase Beta 1, RPS6Kb1, Human, ELISA Kit - E-EL-H1214 from ARP American Research Products
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Ribosomal Protein S6 Kinase Beta 1, RPS6Kb1, Rabbit, ELISA Kit - E-EL-RB0468 from ARP American Research Products
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Ribosomal Protein S6 Kinase Beta 1, RPS6Kb1, Chicken, ELISA Kit - E-EL-Ch1037 from ARP American Research Products
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Ribosomal Protein S6 Kinase Beta 1, RPS6Kb1, Porcine, ELISA Kit - E-EL-P0524 from ARP American Research Products
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Ribosomal Protein S6 Kinase Beta 1, RPS6Kb1, Sheep, ELISA Kit - E-EL-S0243 from ARP American Research Products
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Ribosomal Protein S6 Kinase Beta 1, RPS6Kb1, Monkey, ELISA Kit - E-EL-MK1096 from ARP American Research Products
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