RPS6KB1

Gene Symbol	RPS6KB1
Entrez Gene	6198
Alt Symbol	PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha
Species	Human
Gene Type	protein-coding
Description	ribosomal protein S6 kinase, 70kDa, polypeptide 1
Other Description	p70 S6 kinase, alpha|ribosomal protein S6 kinase I|ribosomal protein S6 kinase beta-1|serine/threonine kinase 14 alpha|serine/threonine-protein kinase 14A
Swissprots	F6UYM1 E7ESB8 B4DTG1 B4DLT4 Q7Z721 B2R779 P23443
Accessions	CAM82744 CDL93497 EAW94382 EAW94383 EAW94384 P23443 AA424792 AI806441 AK026730 AK091503 AK293247 BAG56781 AK297147 BAG59646 AK300202 BAG61973 AK312875 BAG35726 BC030763 BC036033 AAH36033 BC053365 AAH53365 BG614269 BP359158 BQ719717 CA444907 CB050838 M60724 AAA36410 XM_006722010 XP_006722073 XM_011525101 XP_011523403 XM_011525102 XP_011523404 XM_011525103 XP_011523405 XM_011525104 XP_011523406 NM_001272042 NP_001258971 NM_001272043 NP_001258972 NM_001272044 NP_001258973 NM_001272060 NP_001258989 NM_003161 NP_003152
Function	Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein
Subcellular Location	Isoform Alpha II: Cytoplasm.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:9804755}.
Top Pathways	Fc gamma R-mediated phagocytosis, Proteoglycans in cancer, Choline metabolism in cancer, AMPK signaling pathway, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RPS6KB1 293T Cell Transient Overexpression Lysate(Denatured) - H00006198-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

RPS6KB1 overexpression lysate - LY401097 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

RPS6KB1 293 Cell Lysate - 401023 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

p70 S6 Kinase/S6K Overexpression Lysate (Native) - NBL1-15574 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

RPS6KB1 Over-expression Lysate Product - GWB-D35C12 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Human PS6K / RPS6KB1 Insect Cell Lysate (WB positive control) - 10099-H09BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

p70 S6 Kinase/S6K Overexpression Lysate (Denatured) - H00006198-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Human S6K Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175220 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

RPS6KB1-knockout Cell lysate - LC810206 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human RPS6KB1 Knockdown Stable Cell Line - CSC-DC013601 from Creative biogene Category Cell Line Species Human

Human RPS6KB1 Knockout Cell Line-HeLa - CSC-RT0827 from Creative biogene Category Cell Line Species Human

RPS6KB1 KO Cell Lysate-HeLa - CLKO-0330 from Creative biogene Category Cell Lysate

Search more